Increased expression of interferon-gamma in hyperplastic lymph nodes from HIV-infected patients

M. J. Boyle, M. F. Berger, M. Tschuchnigg, J. E. Valentine, B. G. Kennedy, M. Divjak, D. A. Cooper, J. J. Turner, R. Penny, W. A. Sewell*

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Polyclonal B cell activation is characteristic of HIV infection and occurs in the presence of severe CD4+ lymphocyte depletion. In contrast, CD4+ lymphocytcs are the dominant T cell in the reactive lymphoid tissues of patients not infected with HIV. In this study, lymph node biopsies from eight HIV-infected patients with persistent generalized lymphadenopathy syndrome (PGL) were assessed for IL-1β, IL-2, IL-4, IL-6, IL-10, interferon-gamma (IFN-γ) and tumour necrosis factor-beta (TNF-β) gene expression using the polymerase chain reaction (PCR). The cytokine gene expression of two cases of reactive adenopathy in patients not infected with HIV was assessed for comparison. IFN-γ was expressed much more strongly in the PCL ples than in control reactive lymphoid tissues, whereas the other cytokines were expressed to a similar extent in both types of tissues. IFN-γ may have an important role in maintaining the adenopathy of HIV-infected patients. Expression of cytokines such as IL-2, IL-4 and IL-10 in HIV nodes may be adequate to allow the recruitment of naive B cells to the reactive process.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalClinical and Experimental Immunology
Volume92
Issue number1
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • AIDS-related complex
  • cytokines
  • HIV
  • lymphadenopathy syndrome
  • polymerase chain reaction

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