Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease

Kevin Taddei, Roger Clarnette, Samuel E. Gandy, Ralph N. Martins*

*Corresponding author for this work

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

We measured the concentration of apolipoprotein E (apoE) in plasma from 184 non-fasted subjects in order to determine whether important variations might exist linking plasma apoE levels to clinical phenotypes among early and late onset sporadic Alzheimer's disease (AD) and Down's syndrome (DS). A significant increase in the level of plasma apoE was observed in non-fasted late-onset AD patients (with a mean level of 3.26 ± 0.08 μg apoE/mg total protein for n = 84 patients) when compared with the plasma apoE levels of control individuals (mean of 2.32 ± 0.10 μg apoE/mg total protein, n = 51 patients; P < 0.001). A similar increase was found for non-fasted early-onset AD patients (mean of 3.69 ± 0.17 μg apoE/mg total protein, n = 20) when compared with the plasma apoE levels of control individuals (P < 0.001). Plasma apoE levels for DS patients did not differ significantly from those of controls (P > 0.05). The association of elevated plasma apoE levers in AD may be relevant to clarifying the mechanism(s) whereby apoE isoforms specify differential risk for development of AD.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalNeuroscience Letters
Volume223
Issue number1
DOIs
Publication statusPublished - 14 Feb 1997
Externally publishedYes

Keywords

  • β-Amyloid
  • Alzheimer's disease
  • Apolipoprotein E
  • Blood plasma
  • Chromosome 19
  • Down's syndrome
  • Genotypes

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