This study examines the unique effects of spiritual resources in the job demands-resources model beyond those of the 5-factor model of personality. Hypotheses were tested on a sample of 617 religious workers using structural equation modeling techniques. Results showed that various dimensions of personality were significantly related to spiritual resources, work engagement, exhaustion, and the other elements of the job demands-resources model (job demands, job resources, emotional ill-health, and turnover intention). However, spiritual resources were found to demonstrate a significant relationship with both work engagement and exhaustion in the presence of personality dimensions and work characteristics. The contribution of spiritual resources in predicting work engagement was similar to that of personality, although approximately one third of the magnitude of personality in predicting exhaustion. This cross-sectional analysis suggests that spiritual resources are distinctly, albeit modestly, related to well-being at work for religious workers.