Induced pluripotent stem cells: a new era for hepatology

Samira Asgari, Behshad Pournasr, Ghasem Hosseini Salekdeh, Arefeh Ghodsizadeh, Michael Ott, Hossein Baharvand

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.

LanguageEnglish
Pages738-751
Number of pages14
JournalJournal of Hepatology
Volume53
Issue number4
DOIs
Publication statusPublished - 1 Oct 2010
Externally publishedYes

Fingerprint

Induced Pluripotent Stem Cells
Gastroenterology
Artificial Liver
Liver
Cell Transplantation
Stem Cell Transplantation
Tissue Engineering
Cell- and Tissue-Based Therapy
Research
Pharmaceutical Preparations
Genes

Keywords

  • Bio-artificial livers
  • Drug development
  • Gene therapy
  • Hepatology
  • Induced pluripotent stem (iPS) cells
  • Transplantation

Cite this

Asgari, S., Pournasr, B., Salekdeh, G. H., Ghodsizadeh, A., Ott, M., & Baharvand, H. (2010). Induced pluripotent stem cells: a new era for hepatology. Journal of Hepatology, 53(4), 738-751. https://doi.org/10.1016/j.jhep.2010.05.009
Asgari, Samira ; Pournasr, Behshad ; Salekdeh, Ghasem Hosseini ; Ghodsizadeh, Arefeh ; Ott, Michael ; Baharvand, Hossein. / Induced pluripotent stem cells : a new era for hepatology. In: Journal of Hepatology. 2010 ; Vol. 53, No. 4. pp. 738-751.
@article{54d773ddabf84aee9bb156f2b3a33d22,
title = "Induced pluripotent stem cells: a new era for hepatology",
abstract = "Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.",
keywords = "Bio-artificial livers, Drug development, Gene therapy, Hepatology, Induced pluripotent stem (iPS) cells, Transplantation",
author = "Samira Asgari and Behshad Pournasr and Salekdeh, {Ghasem Hosseini} and Arefeh Ghodsizadeh and Michael Ott and Hossein Baharvand",
year = "2010",
month = "10",
day = "1",
doi = "10.1016/j.jhep.2010.05.009",
language = "English",
volume = "53",
pages = "738--751",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "4",

}

Asgari, S, Pournasr, B, Salekdeh, GH, Ghodsizadeh, A, Ott, M & Baharvand, H 2010, 'Induced pluripotent stem cells: a new era for hepatology', Journal of Hepatology, vol. 53, no. 4, pp. 738-751. https://doi.org/10.1016/j.jhep.2010.05.009

Induced pluripotent stem cells : a new era for hepatology. / Asgari, Samira; Pournasr, Behshad; Salekdeh, Ghasem Hosseini; Ghodsizadeh, Arefeh; Ott, Michael; Baharvand, Hossein.

In: Journal of Hepatology, Vol. 53, No. 4, 01.10.2010, p. 738-751.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Induced pluripotent stem cells

T2 - Journal of Hepatology

AU - Asgari, Samira

AU - Pournasr, Behshad

AU - Salekdeh, Ghasem Hosseini

AU - Ghodsizadeh, Arefeh

AU - Ott, Michael

AU - Baharvand, Hossein

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.

AB - Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.

KW - Bio-artificial livers

KW - Drug development

KW - Gene therapy

KW - Hepatology

KW - Induced pluripotent stem (iPS) cells

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=77956265725&partnerID=8YFLogxK

U2 - 10.1016/j.jhep.2010.05.009

DO - 10.1016/j.jhep.2010.05.009

M3 - Review article

VL - 53

SP - 738

EP - 751

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 4

ER -