Induced pluripotent stem cells: a new era for hepatology

Samira Asgari; Behshad Pournasr; Ghasem Hosseini Salekdeh; Arefeh Ghodsizadeh; Michael Ott; Hossein Baharvand

doi:10.1016/j.jhep.2010.05.009

Induced pluripotent stem cells: a new era for hepatology

Samira Asgari, Behshad Pournasr, Ghasem Hosseini Salekdeh, Arefeh Ghodsizadeh, Michael Ott, Hossein Baharvand^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

62 Citations (Scopus)

Abstract

Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.

Original language	English
Pages (from-to)	738-751
Number of pages	14
Journal	Journal of Hepatology
Volume	53
Issue number	4
DOIs	https://doi.org/10.1016/j.jhep.2010.05.009
Publication status	Published - 1 Oct 2010
Externally published	Yes

Keywords

Bio-artificial livers
Drug development
Gene therapy
Hepatology
Induced pluripotent stem (iPS) cells
Transplantation

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10.1016/j.jhep.2010.05.009

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title = "Induced pluripotent stem cells: a new era for hepatology",

abstract = "Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.",

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AU - Asgari, Samira

AU - Pournasr, Behshad

AU - Salekdeh, Ghasem Hosseini

AU - Ghodsizadeh, Arefeh

AU - Ott, Michael

AU - Baharvand, Hossein

PY - 2010/10/1

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AB - Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.

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KW - Drug development

KW - Gene therapy

KW - Hepatology

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Induced pluripotent stem cells: a new era for hepatology

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