Induced pluripotent stem cells

a new era for hepatology

Samira Asgari, Behshad Pournasr, Ghasem Hosseini Salekdeh, Arefeh Ghodsizadeh, Michael Ott, Hossein Baharvand*

*Corresponding author for this work

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.

Original languageEnglish
Pages (from-to)738-751
Number of pages14
JournalJournal of Hepatology
Volume53
Issue number4
DOIs
Publication statusPublished - 1 Oct 2010
Externally publishedYes

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Keywords

  • Bio-artificial livers
  • Drug development
  • Gene therapy
  • Hepatology
  • Induced pluripotent stem (iPS) cells
  • Transplantation

Cite this

Asgari, S., Pournasr, B., Salekdeh, G. H., Ghodsizadeh, A., Ott, M., & Baharvand, H. (2010). Induced pluripotent stem cells: a new era for hepatology. Journal of Hepatology, 53(4), 738-751. https://doi.org/10.1016/j.jhep.2010.05.009