Abstract
Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.
| Language | English |
|---|---|
| Pages | 738-751 |
| Number of pages | 14 |
| Journal | Journal of Hepatology |
| Volume | 53 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Oct 2010 |
| Externally published | Yes |
Fingerprint
Keywords
- Bio-artificial livers
- Drug development
- Gene therapy
- Hepatology
- Induced pluripotent stem (iPS) cells
- Transplantation
Cite this
}
Induced pluripotent stem cells : a new era for hepatology. / Asgari, Samira; Pournasr, Behshad; Salekdeh, Ghasem Hosseini; Ghodsizadeh, Arefeh; Ott, Michael; Baharvand, Hossein.
In: Journal of Hepatology, Vol. 53, No. 4, 01.10.2010, p. 738-751.Research output: Contribution to journal › Review article › Research › peer-review
TY - JOUR
T1 - Induced pluripotent stem cells
T2 - Journal of Hepatology
AU - Asgari, Samira
AU - Pournasr, Behshad
AU - Salekdeh, Ghasem Hosseini
AU - Ghodsizadeh, Arefeh
AU - Ott, Michael
AU - Baharvand, Hossein
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.
AB - Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology.
KW - Bio-artificial livers
KW - Drug development
KW - Gene therapy
KW - Hepatology
KW - Induced pluripotent stem (iPS) cells
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=77956265725&partnerID=8YFLogxK
U2 - 10.1016/j.jhep.2010.05.009
DO - 10.1016/j.jhep.2010.05.009
M3 - Review article
VL - 53
SP - 738
EP - 751
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 4
ER -