Induction of cachexia in mice by systemically administered myostatin

Teresa A. Zimmers, Monique V. Davies, Leonidas G. Koniaris, Paul Haynes, Aurora F. Esquela, Kathy N. Tomkinson, Alexandra C. McPherron, Neil M. Wolfman, Se Jin Lee*

*Corresponding author for this work

Research output: Contribution to journalArticle

659 Citations (Scopus)

Abstract

Mice and cattle with genetic deficiencies in myostatin exhibit dramatic increases in skeletal muscle mass, suggesting that myostatin normally suppresses muscle growth. Whether this increased muscling results from prenatal or postnatal lack of myostatin activity is unknown. Here we show that myostatin circulates in the blood of adult mice in a latent form that can be activated by acid treatment. Systemic overexpression of myostatin in adult mice was found to induce profound muscle and fat loss analogous to that seen in human cachexia syndromes. These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired.

Original languageEnglish
Pages (from-to)1486-1488
Number of pages3
JournalScience
Volume296
Issue number5572
DOIs
Publication statusPublished - 24 May 2002
Externally publishedYes

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  • Cite this

    Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P., Esquela, A. F., Tomkinson, K. N., ... Lee, S. J. (2002). Induction of cachexia in mice by systemically administered myostatin. Science, 296(5572), 1486-1488. https://doi.org/10.1126/science.1069525