Induction of TDO2 and IDO2 in liver by high-fat feeding in mice

Discrepancies with human obesity

Odile Poulain-Godefroy*, Elodie Eury, Audrey Leloire, Benjamin Hennart, Gilles J. Guillemin, Delphine Allorge, Philippe Froguel

*Corresponding author for this work

    Research output: Contribution to journalArticle

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    Abstract

    Low-grade and chronic inflammation is elicited in white adipose tissue in human obesity. The presence of inflammatory molecules leads to an increased tryptophan catabolism through the induction of indoleamine-2,3-dioxygenase-1 (IDO1). In order to characterize the mechanisms underlying this dysregulation, we have studied 2 mouse models of obesity. Unexpectedly, we did not detect any IDO1 expression in obese or lean mice adipose tissue. In a previous study, we did not find any significant difference in the liver for IDO2 and tryptophan-2,3-dioxygenase (TDO2) gene expression between normal weight and obese patients. IDO2 and TDO2 expression was increased in the liver of high-fat fed mice, but not in ob/ob mice, and was strongly correlated with hydroxysteroid- (11-beta) dehydrogenase-1 (HSD11B1) expression, an enzyme that generates active cortisol within tissues. In conclusion, despite a dysregulation of tryptophan metabolism, obese mice display discrepancies with human obesity metabolism, rendering them inappropriate for further investigations in this animal model.

    Original languageEnglish
    Pages (from-to)29-37
    Number of pages9
    JournalInternational Journal of Tryptophan Research
    Volume6
    Issue numberSUPPL.1
    DOIs
    Publication statusPublished - 2013

    Bibliographical note

    Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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