Infantile-onset myelin protein zero-related demyelinating neuropathy presenting as an upper extremity monoplegia

Eppie M. Yiu*, Jithangi Wanigasinghe, Mark T. Mackay, Michael Gonzales, Garth A. Nicholson, Monique M. Ryan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We describe an infant with an early-onset demyelinating neuropathy who presented with an upper extremity monoplegia and progressive asymmetric weakness. Neurophysiologic testing revealed a generalized severe neuropathy with marked slowing of nerve conduction. The disproportionate severity and asymmetry of upper extremity involvement at presentation was atypical of inherited neuropathies, and an initial diagnosis of chronic inflammatory demyelinating polyneuropathy was considered. Nerve biopsy showed severe depletion of large myelinated fibers without inflammatory cells, and focally folded myelin sheaths were seen on electron microscopy. Genetic testing revealed a de novo heterozygous mutation in the myelin protein zero gene.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalSeminars in Pediatric Neurology
Early online date1 Apr 2017
Publication statusPublished - Jul 2018
Externally publishedYes

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