Infection and transport of herpes simplex virus type 1 in neurons

role of the cytoskeleton

Monica Miranda-Saksena, Christopher E. Denes, Russell J. Diefenbach, Anthony L. Cunningham

Research output: Contribution to journalReview article

28 Citations (Scopus)
20 Downloads (Pure)

Abstract

Herpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Therefore, HSV-1 has adapted mechanisms to promote its survival by exploiting the microtubule and actin cytoskeletons to direct its active transport, infection, and spread between neurons and epithelial cells during primary and recurrent infections. This review will focus on the currently known mechanisms utilized by HSV-1 to harness the neuronal cytoskeleton, molecular motors, and the secretory and exocytic pathways for efficient virus entry, axonal transport, replication, assembly, and exit from the distinct functional compartments (cell body and axon) of the highly polarized sensory neurons.
Original languageEnglish
Article number92
Pages (from-to)1-20
Number of pages20
JournalViruses
Volume10
Issue number2
DOIs
Publication statusPublished - 23 Feb 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • herpes simplex virus
  • Neurons
  • Axonal transport
  • cytoskeleton
  • microtubules
  • actin

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