Infection and transport of herpes simplex virus type 1 in neurons: role of the cytoskeleton

Monica Miranda-Saksena, Christopher E. Denes, Russell J. Diefenbach, Anthony L. Cunningham

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    54 Citations (Scopus)
    87 Downloads (Pure)

    Abstract

    Herpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Therefore, HSV-1 has adapted mechanisms to promote its survival by exploiting the microtubule and actin cytoskeletons to direct its active transport, infection, and spread between neurons and epithelial cells during primary and recurrent infections. This review will focus on the currently known mechanisms utilized by HSV-1 to harness the neuronal cytoskeleton, molecular motors, and the secretory and exocytic pathways for efficient virus entry, axonal transport, replication, assembly, and exit from the distinct functional compartments (cell body and axon) of the highly polarized sensory neurons.
    Original languageEnglish
    Article number92
    Pages (from-to)1-20
    Number of pages20
    JournalViruses
    Volume10
    Issue number2
    DOIs
    Publication statusPublished - 23 Feb 2018

    Bibliographical note

    Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    Keywords

    • herpes simplex virus
    • Neurons
    • Axonal transport
    • cytoskeleton
    • microtubules
    • actin

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