Infections and use of antibiotics in patients admitted for severe acute pancreatitis

data from the EPIC II study

Jan J. De Waele*, Jordi Rello, Antonio Anzueto, Rui Moreno, Jeffrey Lipman, Yasser Sakr, Peter Pickkers, Marc Leone, Andrew Ferguson, Lavi Oud, Jean Louis Vincent, EPIC II Investigators

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)


Background: Infectious complications are frequent in severe acute pancreatitis (SAP) but multinational epidemiologic data are lacking. The aim of the study was to analyze the characteristics of the infectious complications and antimicrobial use in this setting. Methods: One-day point prevalence study of infection in critically ill patients (Extended Prevalence of Infection in the ICU-II study), performed in 1,265 ICUs in 75 countries. Results: Of the 13,796 patients in the study, 159 were admitted with SAP. One-hundred sixteen (73%) had infections: 31% intra-abdominal, 16% extra-abdominal, and 26% both. Gram-negative bacteria were more prevalent than gram-positive organisms, anaerobes, or fungi. Therapeutically, penicillins and other beta-lactams were used most frequently. Prophylactic antibiotics were administered to 24% of the patients with SAP. Conclusions: Infections are frequent in patients admitted with SAP; most are intra-abdominal infections. Microbiology is diverse with gram-negative micro-organisms most frequently isolated. Most patients admitted to the ICU for SAP receive antibiotics at some point.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalSurgical Infections
Issue number4
Publication statusPublished - 1 Aug 2014
Externally publishedYes

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