Inflammatory and thrombotic changes in early bereavement: A prospective evaluation

Thomas Buckley, Marie Christine Morel-Kopp, Christopher Ward, Roger Bartrop, Sharon McKinley, Anastasia Susie Mihailidou, Monica Spinaze, Walter Chen, Geoffrey Tofler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Aims: Although there is an increased cardiovascular risk in the immediate weeks following bereavement, the mechanism is not well understood. The aim of this study was to determine whether inflammatory and thrombotic changes were present in acute bereavement. Methods and results: Eighty bereaved spouses or parents were prospectively studied within 2 weeks of bereavement (acute) and at 6 months, and compared to 80 non-bereaved participants. Haemostatic measures were obtained between 8 a.m. and 11 a.m. and processed within 1 h. Compared to non-bereaved participants, those acutely bereaved had a higher neutrophil count (4.34 ± 0.19 vs 3.79 ± 0.15, p = <0.001), von Willebrand factor antigen (132.33 ± 3.6 vs 119.95 ± 3.29, p = 0.02), Factor VIII (1.43 ± 0.06 vs 1.25 ± 0.04, p = 0.02) and platelet/granulocyte aggregates (median 383.0 vs 343.5, p = 0.02). Levels of neutrophils, monocytes, eosinophils, platelet count, platelet/monocyte granulocytes and von Willebrand factor were lower in bereaved at 6 months compared to acutely (all p < 0.05).Conclusion: Acute bereavement is associated with inflammatory and prothrombotic changes that may contribute to the increased cardiovascular risk with bereavement and provide clues for future preventative strategies.

Original languageEnglish
Pages (from-to)1145-1152
Number of pages8
JournalEuropean Journal of Preventive Cardiology
Issue number5
Publication statusPublished - Oct 2012
Externally publishedYes


  • Bereavement
  • inflammation
  • platelet
  • thrombotic changes
  • von Willebrand


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