Influence of kavain on hepatic ultrastructure

Shuang Fu, Emine Korkmaz, Filip Braet, Quan Ngo, Iqbal Ramzan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Aim: To investigate whether the major kavalactone kavain imposes adverse effects on the liver ultrastructure and function by affecting vascular and microvascular architecture and altering hepatocellular morphology. Methods: Kavain solution (10 μg/mL or 43.5 μmol/L) was perfused for 2 h in isolated rat livers. After standard fixation and tissue preparation, the samples were examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and light microscopy (LM). Results: LM, SEM, and TEM examinations indicated kavain-treated rat livers (n = 4) displayed severe vascular and endothelial damage compared to control livers (n = 4). Conclusion: The data so far support the hypothesis that kavain induces adverse effects on liver; additional investigations with other kavalactones and their effects on liver are urgently needed.

Original languageEnglish
Pages (from-to)541-546
Number of pages6
JournalWorld Journal of Gastroenterology
Issue number4
Publication statusPublished - 28 Jan 2008
Externally publishedYes


  • Electron microscopy
  • Kava
  • Kavain
  • Kavalactones
  • Liver


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