Influence of nutritional status on growth hormone-dependent circulating somatomedin-C activity in mature sheep

P. C. Wynn, M. C. Stuart, A. L C Wallace, A. C. Kirby, E. F. Annison

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Abstract

The effect of daily administration of ovine GH for a period of 4 weeks on somatomedin-C biological activity in plasma was investigated in mature Merino sheep fed a maintenance energy intake (low plane; LP) or 1.6 times this amount (high plane; HP). The GH treatment resulted in a significant (P < 0.05) increase in plasma GH levels in blood samples collected 23.5 h after each daily injection in both LP and HP groups. Plasma concentrations of somatomedin-C activity and insulin were significantly stimulated to a maximum level by the third GH injection and remained at this level for 7 days. Subsequently, circulating levels of both hormones fell to 40-50% of the peak response to GH and returned to basal levels within 48 h of the cessation of GH injections. In the HP group the response of plasma insulin and somatomedin-C activity to GH injection was greater than in the LP group.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalJournal of Endocrinology
Volume130
Issue number2
Publication statusPublished - 1991

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    Wynn, P. C., Stuart, M. C., Wallace, A. L. C., Kirby, A. C., & Annison, E. F. (1991). Influence of nutritional status on growth hormone-dependent circulating somatomedin-C activity in mature sheep. Journal of Endocrinology, 130(2), 313-320.