Influence of time to achieve target systolic blood pressure on outcome after intracerebral hemorrhage: the Blood Pressure in Acute Stroke Collaboration

Xia Wang, Jie Yang, Tom J. Moullaali, Else Charlotte Sandset, Lisa J. Woodhouse, Zhe Kang Law, Hisatomi Arima, Kenneth S. Butcher, Candice Delcourt, Leon Edwards, Salil Gupta, Wen Jiang, Sebastian Koch, John Potter, Adnan I. Qureshi, Thompson G. Robinson, Rustam Al-Shahi Salman, Jeffrey L. Saver, Nikola Sprigg, Joanna WardlawCraig S. Anderson, Yuki Sakamoto, Philip M. Bath, John Chalmers, The Blood Pressure in Acute Stroke (BASC) Investigators

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To investigate whether an earlier time to achieving and maintaining systolic blood pressure (SBP) at 120 to 140 mm Hg is associated with favorable outcomes in a cohort of patients with acute intracerebral hemorrhage.

METHODS: We pooled individual patient data from randomized controlled trials registered in the Blood Pressure in Acute Stroke Collaboration. Time was defined as time form symptom onset plus the time (hour) to first achieve and subsequently maintain SBP at 120 to 140 mm Hg over 24 hours. The primary outcome was functional status measured by the modified Rankin Scale at 90 to 180 days. A generalized linear mixed models was used, with adjustment for covariables and trial as a random effect.

RESULTS: A total of 5761 patients (mean age, 64.0 [SD, 13.0], 2120 [36.8%] females) were included in analyses. Earlier SBP control was associated with better functional outcomes (modified Rankin Scale score, 3–6; odds ratio, 0.98 [95% CI, 0.97–0.99]) and a significant lower risk of hematoma expansion (0.98, 0.96–1.00). This association was stronger in patients with bigger baseline hematoma volume (>10 mL) compared with those with baseline hematoma volume ≤10 mL (0.006 for interaction). Earlier SBP control was not associated with cardiac or renal adverse events.

CONCLUSIONS: Our study confirms a clear time relation between early versus later SBP control (120–140 mm Hg) and outcomes in the one-third of patients with intracerebral hemorrhage who attained sustained SBP levels within this range. These data provide further support for the value of early recognition, rapid transport, and prompt initiation of treatment of patients with intracerebral hemorrhage.
Original languageEnglish
Pages (from-to)849-855
Number of pages7
Issue number4
Early online date27 Feb 2024
Publication statusPublished - 1 Apr 2024


  • adults
  • blood pressure
  • cerebral hemorrhage
  • hematoma
  • stroke


Dive into the research topics of 'Influence of time to achieve target systolic blood pressure on outcome after intracerebral hemorrhage: the Blood Pressure in Acute Stroke Collaboration'. Together they form a unique fingerprint.

Cite this