Inhalation of nanoparticle-based drug for lung cancer treatment: advantages and challenges

Wing-Hin Lee, Ching-Yee Loo, Daniela Traini, Paul M. Young

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)
40 Downloads (Pure)

Abstract

Ever since the success of developing inhalable insulin, drug delivery via pulmonary administration has become an attractive route to treat chronic diseases. Pulmonary delivery system for nanotechnology is a relatively new concept especially when applicable to lung cancer therapy. Nano-based systems such as liposome, polymeric nanoparticles or micelles are strategically designed to enhance the therapeutic index of anti-cancer drugs through improvement of their bioavailability, stability and residency at targeted lung regions. Along with these benefits, nano-based systems also provide additional diagnostic advantages during lung cancer treatment, including imaging, screening and drug tracking. Nevertheless, delivery of nano-based drugs via pulmonary administration for lung cancer therapy is still in its infancy and numerous challenges are expected. Pharmacology, immunology, toxicology and large-scale manufacturing (stability and activity of drugs) are some aspects in nanotechnology that should be taken into consideration for the development of inhalable nano-based chemotherapeutic drugs. This review will focus on the current inhalable nano-based drugs for lung cancer treatment.
Original languageEnglish
Pages (from-to)481-489
Number of pages9
JournalAsian Journal of Pharmaceutical Sciences
Volume10
Issue number6
DOIs
Publication statusPublished - 2015
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Inhalation
  • Lung cancer
  • Liposome
  • Nanoparticle

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