Inhibition of cardiac baroreflex sensitivity after central dopaminergic stimulation

Maarten Van Den Buuse, David P. Wilks, Jennifer L. Cornish

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


1. Stimulation of the mesolimbic dopamine system, by microinjection of the substance P analogue [pGlu5,MePhe8,Sar9]substance P (DiMe-C7) into the ventral tegmental area induced a prolonged increase in blood pressure and circulating levels of vasopressin. 2. In the present study, this treatment produced a significant decrease of cardiac baroreflex sensitivity in conscious rats. After pretreatment with the dopamine receptor antagonist raclopride, central stimulation failed to produce any changes in baroreflex parameters. 3. The central dopamine-mediated decrease in baroreflex sensitivity may beinvolved in functionally potentiating the circulatory actions of vasopressin.

Original languageEnglish
Pages (from-to)624-626
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Issue number7-8
Publication statusPublished - 1998
Externally publishedYes


  • Baroreflex
  • Dopamine
  • Mesolimbic system
  • Vasopressin
  • Ventral tegmental area


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