Inhibition of GP 120 and antibodies binding to CD 4 by metal complexes of promazines

S. E. Kidd; M. J. Nelson; M. Epstein; A. Aszalos; S. Pine; J. Molnar

Inhibition of GP 120 and antibodies binding to CD 4 by metal complexes of promazines

S. E. Kidd^*, M. J. Nelson, M. Epstein, A. Aszalos, S. Pine, J. Molnar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

One approach to decrease infectivity of HIV is to prevent binding of its surface protein gp120 to the CD4 molecule of T lymphocytes. We show here that Pd, Au and Cu complexes of promazine and chlorpromazine inhibit the binding of Leu3a mAb and rgp120 to CD4 expressing cells. The fusion of gp120 expressing and CD4 expressing cells was affected as well. These effects are due to nonspecific membrane effects of the metal-complexes on cell surface molecules.

Original language	English
Pages (from-to)	71-77
Number of pages	7
Journal	Antiinfective Drugs and Chemotherapy
Volume	15
Issue number	2-3
Publication status	Published - 1997

Keywords

CD4
complex
gp120
HIV
phenothiazine

Cite this

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abstract = "One approach to decrease infectivity of HIV is to prevent binding of its surface protein gp120 to the CD4 molecule of T lymphocytes. We show here that Pd, Au and Cu complexes of promazine and chlorpromazine inhibit the binding of Leu3a mAb and rgp120 to CD4 expressing cells. The fusion of gp120 expressing and CD4 expressing cells was affected as well. These effects are due to nonspecific membrane effects of the metal-complexes on cell surface molecules.",

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AU - Kidd, S. E.

AU - Nelson, M. J.

AU - Epstein, M.

AU - Aszalos, A.

AU - Pine, S.

AU - Molnar, J.

PY - 1997

Y1 - 1997

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AB - One approach to decrease infectivity of HIV is to prevent binding of its surface protein gp120 to the CD4 molecule of T lymphocytes. We show here that Pd, Au and Cu complexes of promazine and chlorpromazine inhibit the binding of Leu3a mAb and rgp120 to CD4 expressing cells. The fusion of gp120 expressing and CD4 expressing cells was affected as well. These effects are due to nonspecific membrane effects of the metal-complexes on cell surface molecules.

KW - CD4

KW - complex

KW - gp120

KW - HIV

KW - phenothiazine

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IS - 2-3

ER -

Inhibition of GP 120 and antibodies binding to CD 4 by metal complexes of promazines

Abstract

Keywords

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