TY - JOUR
T1 - Inhibition of transketolase and pyruvate decarboxylase by omeprazole
AU - Nixon, Peter F.
AU - Diefenbach, Russell J.
AU - Duggleby, Ronald G.
PY - 1992/7/7
Y1 - 1992/7/7
N2 - Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki, value of 42 ± 3 μM, whereas inhibition of TK was complex.
AB - Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki, value of 42 ± 3 μM, whereas inhibition of TK was complex.
UR - http://www.scopus.com/inward/record.url?scp=0026664248&partnerID=8YFLogxK
U2 - 10.1016/0006-2952(92)90053-L
DO - 10.1016/0006-2952(92)90053-L
M3 - Article
C2 - 1632833
AN - SCOPUS:0026664248
SN - 0006-2952
VL - 44
SP - 177
EP - 179
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 1
ER -