Inhibition of transketolase and pyruvate decarboxylase by omeprazole

Peter F. Nixon*, Russell J. Diefenbach, Ronald G. Duggleby

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC, PDC) from Zymomonas mobilis and transketolase (EC, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki, value of 42 ± 3 μM, whereas inhibition of TK was complex.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalBiochemical Pharmacology
Issue number1
Publication statusPublished - 7 Jul 1992
Externally publishedYes


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