Inhibition of transketolase and pyruvate decarboxylase by omeprazole

Peter F. Nixon*, Russell J. Diefenbach, Ronald G. Duggleby

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki, value of 42 ± 3 μM, whereas inhibition of TK was complex.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalBiochemical Pharmacology
Volume44
Issue number1
DOIs
Publication statusPublished - 7 Jul 1992
Externally publishedYes

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