Inhibition of transketolase and pyruvate decarboxylase by omeprazole

Peter F. Nixon; Russell J. Diefenbach; Ronald G. Duggleby

doi:10.1016/0006-2952(92)90053-L

Inhibition of transketolase and pyruvate decarboxylase by omeprazole

Peter F. Nixon^*, Russell J. Diefenbach, Ronald G. Duggleby

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a K_i, value of 42 ± 3 μM, whereas inhibition of TK was complex.

Original language	English
Pages (from-to)	177-179
Number of pages	3
Journal	Biochemical Pharmacology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/0006-2952(92)90053-L
Publication status	Published - 7 Jul 1992
Externally published	Yes

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10.1016/0006-2952(92)90053-L

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title = "Inhibition of transketolase and pyruvate decarboxylase by omeprazole",

abstract = "Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki, value of 42 ± 3 μM, whereas inhibition of TK was complex.",

author = "Nixon, \{Peter F.\} and Diefenbach, \{Russell J.\} and Duggleby, \{Ronald G.\}",

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AU - Nixon, Peter F.

AU - Diefenbach, Russell J.

AU - Duggleby, Ronald G.

PY - 1992/7/7

Y1 - 1992/7/7

N2 - Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki, value of 42 ± 3 μM, whereas inhibition of TK was complex.

AB - Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki, value of 42 ± 3 μM, whereas inhibition of TK was complex.

UR - https://www.scopus.com/pages/publications/0026664248

U2 - 10.1016/0006-2952(92)90053-L

DO - 10.1016/0006-2952(92)90053-L

M3 - Article

C2 - 1632833

AN - SCOPUS:0026664248

SN - 0006-2952

VL - 44

SP - 177

EP - 179

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 1

ER -

Inhibition of transketolase and pyruvate decarboxylase by omeprazole

Abstract

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