Insight into autonomic nervous system control of heart rate in the rat using analysis of heart rate variability and baroreflex sensitivity

Cara M. Hildreth*, Ann K. Goodchild, Jacqueline K. Phillips

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Citations (Scopus)

Abstract

Heart rate variability and baroreflex sensitivity are two readily accessible methods available to assess control of heart rate by the autonomic nervous system. Heart rate variability can provide information regarding neural (parasympathetic, sympathetic, reflex) and nonneural (hormones, thermoregulation) control of heart rate. Baroreflex sensitivity provides information on how effective the autonomic nervous system is in rapidly changing heart rate in response to changes in blood pressure. Methods are presented on how to calculate heart rate variability using frequency domain analysis and how to calculate baroreflex sensitivity using the sequence method and α-coefficient method of analysis. Data is presented from a variety of rat strains (control, hypertensive, kidney disease, depressed) to indicate the utility of these methods for comparing autonomic regulation of the heart in both anaesthetised animals via intra-arterial recordings and conscious animals using telemetry.

Original languageEnglish
Title of host publicationStimulation and Inhibition of Neurons
EditorsPaul M. Pilowsky, Melissa M. J. Farnham, Angelina Y. Fong
Place of PublicationNew York
PublisherHumana Press
Pages203-223
Number of pages21
ISBN (Electronic)9781627032339
ISBN (Print)9781627032322
DOIs
Publication statusPublished - 2013

Publication series

NameNeuromethods
Volume78
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • α-Coefficient
  • Baroreflex sensitivity
  • Frequency domain analysis
  • Heart rate variability
  • Radiotelemetry
  • Sequence method

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