Integrated proteomics identified up-regulated focal adhesion-mediated proteins in human squamous cell carcinoma in an orthotopic murine model

Daniela C. Granato, Mariana R. Zanetti, Rebeca Kawahara, Sami Yokoo, Romenia R. Domingues, Annelize Z. Aragao, Michelle Agostini, Marcelo F. Carazzolle, Ramon O. Vidal, Isadora L. Flores, Johanna Korvala, Nilva K. Cervigne, Alan R. S. Silva, Ricardo D. Coletta, Edgard Graner, Nicholas E. Sherman, Adriana F. Paes Leme

Research output: Contribution to journalArticle

7 Citations (Scopus)
3 Downloads (Pure)

Abstract

Understanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral squamous cell carcinoma (OSCC), mass spectrometry-based proteomics and biological network analysis. Our results indicated the up-regulation of proteins involved in actin cytoskeleton organization and cell-cell junction assembly events and their expression was validated in human OSCC tissues. In addition, the functional relevance of talin-1 in OSCC adhesion, migration and invasion was demonstrated. Taken together, this study identified specific processes deregulated in oral cancer and provided novel refined OSCC-targeting molecules.
Original languageEnglish
Article numbere98208
Number of pages11
JournalPLoS ONE
Volume9
Issue number5
DOIs
Publication statusPublished - 23 May 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Fingerprint Dive into the research topics of 'Integrated proteomics identified up-regulated focal adhesion-mediated proteins in human squamous cell carcinoma in an orthotopic murine model'. Together they form a unique fingerprint.

  • Cite this

    Granato, D. C., Zanetti, M. R., Kawahara, R., Yokoo, S., Domingues, R. R., Aragao, A. Z., ... Paes Leme, A. F. (2014). Integrated proteomics identified up-regulated focal adhesion-mediated proteins in human squamous cell carcinoma in an orthotopic murine model. PLoS ONE, 9(5), [e98208]. https://doi.org/10.1371/journal.pone.0098208