Intelligence and executive functions in frontotemporal dementia

María Roca*, Facundo Manes, Ezequiel Gleichgerrcht, Peter Watson, Agustín Ibáñez, Russell Thompson, Teresa Torralva, John Duncan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Recently (Roca et al. (2010), we used the relationship with general intelligence (Spearman's g) to define two sets of frontal lobe or "executive" tests. For one group, including Wisconsin card sorting and verbal fluency, reduction in g entirely explained the deficits found in frontal patients. For another group, including tests of social cognition and multitasking, frontal deficits remained even after correction for g. Preliminary evidence suggested a link of the latter tasks to more anterior frontal regions. Here we develop this distinction in the context of behavioural-variant frontotemporal dementia (bvFTD), a disorder which progressively affects frontal lobe cortices. In bvFTD, some executive tests, including tests of social cognition and multitasking, decline from the early stage of the disease, while others, including classical executive tests such as Wisconsin card sorting, verbal fluency or Trail Making Test part B, show deficits only later on. Here we show that, while deficits in the classical executive tests are entirely explained by g, deficits in the social cognition and multitasking tests are not. The results suggest a relatively selective cognitive deficit at mild stages of the disease, followed by more widespread cognitive decline well predicted by g.

Original languageEnglish
Pages (from-to)725-730
Number of pages6
JournalNeuropsychologia
Volume51
Issue number4
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

Keywords

  • Executive functions
  • Fluid intelligence
  • Frontotemporal dementia
  • Multitasking
  • Theory of mind

Fingerprint

Dive into the research topics of 'Intelligence and executive functions in frontotemporal dementia'. Together they form a unique fingerprint.

Cite this