Interaction of large artery stiffness and baroreceptor function explored through multiple measurement techniques: a pilot study

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

Baroreceptors, sensors that play a role in controlling arterial blood pressure (BP), are mechanical stretch receptors located in the aortic arch and carotid sinuses. Factors affecting the degree of stretch in the vessel wall with BP, such as increased arterial stiffness, may compromise baroreceptor sensitivity (BRS) to BP changes. Yet, evidence of this is scattered, as both baroreceptor sensitivity (BRS) and arterial stiffness are calculated variables with multiple methodological approaches. This pilot study (n=10) investigates the correlation of arterial stiffness and BRS using multiple BRS calculation techniques (spectral and sequence methodologies at aortic and finger sites) and arterial stiffness measurement [carotid-femoral pulse wave velocity (cfPWV), carotid compliance and distensibility]. BRS was assessed under resting BP conditions and during BP altered by maneuvers (0.1 Hz controlled breathing and leg ischemia). Magnitude of arterial stiffness - BRS correlation was positive for carotid distensibility and compliance, and negative for cfPWV, supporting the theory. A sample size of 100 participants (not rounded - exact figure by power calculation) would be required to confirm or reject all permutations of correlation between BRS by multiple calculation methods and large artery stiffness by PWV and compliance/distensibility measures.

Original languageEnglish
Title of host publication2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Conference (EMBC)
Place of PublicationUSA
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Number of pages4
ISBN (Electronic)9798350324471
DOIs
Publication statusPublished - 1 Jul 2023
EventAnnual International Conference of the IEEE Engineering in Medicine and Biology Conference (45th : 2023) - Sydney, Australia
Duration: 24 Jul 202327 Jul 2023

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology Society
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Volume2023
ISSN (Electronic)2694-0604

Conference

ConferenceAnnual International Conference of the IEEE Engineering in Medicine and Biology Conference (45th : 2023)
Abbreviated titleEMBC 2023
Country/TerritoryAustralia
CitySydney
Period24/07/2327/07/23

Keywords

  • Humans
  • Pressoreceptors
  • Pilot Projects
  • Pulse Wave Analysis
  • Carotid Arteries
  • Arterial Pressure
  • arterial stiffness
  • blood pressure
  • baroreceptor sensitivity
  • pulse wave velocity
  • distensibility
  • compliance
  • aorta
  • carotid artery

Fingerprint

Dive into the research topics of 'Interaction of large artery stiffness and baroreceptor function explored through multiple measurement techniques: a pilot study'. Together they form a unique fingerprint.

Cite this