Interactions between primary sclerosing cholangitis and inflammatory bowel disease

implications in the adult liver transplant setting

Ken Liu, Simone I. Strasser, David J. Koorey, Rupert W. Leong, Michael Solomon, Geoffrey W. McCaughan*

*Corresponding author for this work

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Introduction: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease which is associated with inflammatory bowel disease (IBD) in most cases. As there is currently no medical therapy which alters the natural history of PSC, liver transplantation may be required. Areas covered: We searched for articles in PubMed and critically reviewed current literature on the interrelationship between PSC and IBD with a specific focus on considerations for patients in the liver transplant setting. Expert commentary: PSC is an uncommon disease which limits available studies to be either retrospective or contain relatively small numbers of patients. Based on observations from these studies, the behavior and complications of PSC and IBD impact on each other both before and after a liver transplant. Both these autoimmune conditions and their associated cancer risk also influence patient selection for transplantation and may be impacted by immunosuppression use post-transplant. Hence, a complex interplay exists between PSC, IBD and liver transplantation which requires clarification with ongoing research.

Original languageEnglish
Pages (from-to)949-960
Number of pages12
JournalExpert Review of Gastroenterology and Hepatology
Volume11
Issue number10
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Keywords

  • Cholangiocarcinoma
  • Colorectal cancer
  • Crohn’s disease
  • Inflammatory bowel disease
  • Liver transplantation
  • Primary sclerosing cholangitis
  • Ulcerative colitis

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