Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk

G. Roberts, W. Wen, A. Frankland, T. Perich, E. Holmes-Preston, F. Levy, R. K. Lenroot, D. Hadzi-Pavlovic, J. I. Nurnberger, M. Breakspear, P. B. Mitchell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and in individuals at familial risk who have not yet passed the peak age of onset. Method WM integrity was examined in 63 BD subjects, 150 high-risk (HR) individuals and 111 participants with no family history of mental illness (CON). All subjects were aged 12 to 30 years. Results This young BD group had significantly lower fractional anisotropy within the genu of the corpus callosum (CC) compared with the CON and HR groups. Moreover, the abnormality in the genu of the CC was also present in HR participants with recurrent major depressive disorder (MDD) (n = 16) compared with CON participants. Conclusions Our findings provide important validation of interhemispheric abnormalities in BD patients. The novel finding in HR subjects with recurrent MDD - a group at particular risk of future hypo/manic episodes - suggests that this may potentially represent a trait marker for BD, though this will need to be confirmed in longitudinal follow-up studies.

Original languageEnglish
Pages (from-to)2385-2396
Number of pages12
JournalPsychological Medicine
Issue number11
Publication statusPublished - 1 Aug 2016
Externally publishedYes


  • Bipolar disorder
  • diffusion tensor imaging
  • fractional anisotropy
  • genetic risk
  • tract-based spatial statistics


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