Interleukin-12 and interferon-γ are not detectable in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Lara S. Ford, Dominic B. Rowe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The cause of sporadic amyotrophic lateral sclerosis (SALS) is unknown. We investigated the immune-mediated inflammatory hypothesis of SALS by assaying interleukin-12 (IL-12), interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in the cerebrospinal fluid (CSF) of patients with SALS. These cytokines were measured in the CSF from patients with SALS (n=11), patients with immune-mediated inflammatory central nervous system or nerve root disorders (n=12), and patients with other neurological diseases (n=15) by high sensitivity sandwich enzyme linked immunosorbent assay (ELISA). All samples were below the assay detection limits of O.5 pg/ml for IL-12 and 8 pg/ml for IFN-γ. There was no difference between the groups in the mean concentration of IL-6. There is no evidence in cerebrospinal fluid for induction of a TH1 immune response in SALS.

Original languageEnglish
Pages (from-to)118-120
Number of pages3
JournalAmyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 2004
Externally publishedYes

Keywords

  • Amyotrophic lateral sclerosis
  • Cerebrospinal fluid
  • Cytokines
  • Enzyme-linked immunosorbent assay
  • Motor neuron disease

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