The cause of sporadic amyotrophic lateral sclerosis (SALS) is unknown. We investigated the immune-mediated inflammatory hypothesis of SALS by assaying interleukin-12 (IL-12), interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in the cerebrospinal fluid (CSF) of patients with SALS. These cytokines were measured in the CSF from patients with SALS (n=11), patients with immune-mediated inflammatory central nervous system or nerve root disorders (n=12), and patients with other neurological diseases (n=15) by high sensitivity sandwich enzyme linked immunosorbent assay (ELISA). All samples were below the assay detection limits of O.5 pg/ml for IL-12 and 8 pg/ml for IFN-γ. There was no difference between the groups in the mean concentration of IL-6. There is no evidence in cerebrospinal fluid for induction of a TH1 immune response in SALS.
|Number of pages||3|
|Journal||Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders|
|Publication status||Published - Jun 2004|
- Amyotrophic lateral sclerosis
- Cerebrospinal fluid
- Enzyme-linked immunosorbent assay
- Motor neuron disease