International consensus statement on allergy and rhinology: rhinosinusitis

Richard R. Orlandi*, Todd T. Kingdom, Peter H. Hwang, Timothy L. Smith, Jeremiah A. Alt, Fuad M. Baroody, Pete S. Batra, Manuel Bernal-Sprekelsen, Neil Bhattacharyya, Rakesh K. Chandra, Alexander Chiu, Martin J. Citardi, Noam A. Cohen, John Delgaudio, Martin Desrosiers, Hun-Jong Dhong, Richard Douglas, Berrylin Ferguson, Wytske J. Fokkens, Christos GeorgalasAndrew Goldberg, Jan Gosepath, Daniel L. Hamilos, Joseph K. Han, Richard Harvey, Peter Hellings, Claire Hopkins, Roger Jankowski, Amin R. Javer, Robert Kern, Stilianos Kountakis, Marek L. Kowalski, Andrew Lane, Donald C. Lanza, Richard Lebowitz, Heung-Man Lee, Sandra Y. Lin, Valerie Lund, Amber Luong, Wolf Mann, Bradley F. Marple, Kevin C. Mcmains, Ralph Metson, Robert Naclerio, Jayakar V. Nayak, Nobuyoshi Otori, James N. Palmer, Sanjay R. Parikh, Desiderio Passali, Anju Peters, Jay Piccirillo, David M. Poetker, Alkis J. Psaltis, Hassan H. Ramadan, Vijay R. Ramakrishnan, Herbert Riechelmann, Hwan-Jung Roh, Luke Rudmik, Raymond Sacks, Rodney J. Schlosser, Brent A. Senior, Raj Sindwani, James A. Stankiewicz, Michael Stewart, Bruce K. Tan, Elina Toskala, Richard Voegels, De Yun Wang, Erik K. Weitzel, Sarah Wise, Bradford A. Woodworth, Peter-John Wormald, Erin D. Wright, Bing Zhou, David W. Kennedy

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    682 Citations (Scopus)


    Background: The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods: Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results: The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AECRS), and pediatric RS. Conclusion: As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too often the foundation upon which these recommendations are based is comprised of lower-level evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed.

    Original languageEnglish
    Pages (from-to)S22-S209
    Number of pages188
    JournalInternational Forum of Allergy and Rhinology
    Issue numberSuppl.1
    Publication statusPublished - Feb 2016


    • Acute rhinosinusitis
    • Chronic rhinosinusitis
    • Endoscopic sinus surgery
    • Evidence-based medicine
    • Recurrent acute rhinosinusitis
    • Rhinosinusitis
    • Systematic review


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