International consensus statement on allergy and rhinology: rhinosinusitis 2021

Richard R. Orlandi*, Todd T. Kingdom, Timothy L. Smith, Benjamin Bleier, Adam DeConde, Amber U. Luong, David M. Poetker, Zachary Soler, Kevin C. Welch, Sarah K. Wise, Nithin Adappa, Jeremiah A. Alt, Wilma Terezinha Anselmo-Lima, Claus Bachert, Fuad M. Baroody, Pete S. Batra, Manuel Bernal-Sprekelsen, Daniel Beswick, Neil Bhattacharyya, Rakesh K. ChandraEugene H. Chang, Alexander Chiu, Naweed Chowdhury, Martin J. Citardi, Noam A. Cohen, David B. Conley, John DelGaudio, Martin Desrosiers, Richard Douglas, Jean Anderson Eloy, Wytske J. Fokkens, Stacey T. Gray, David A. Gudis, Daniel L. Hamilos, Joseph K. Han, Richard Harvey, Peter Hellings, Eric H. Holbrook, Claire Hopkins, Peter Hwang, Amin R. Javer, Rong San Jiang, David Kennedy, Robert Kern, Tanya Laidlaw, Devyani Lal, Andrew Lane, Heung Man Lee, Jivianne T. Lee, Joshua M. Levy, Sandra Y. Lin, Valerie Lund, Kevin C. McMains, Ralph Metson, Joaquim Mullol, Robert Naclerio, Gretchen Oakley, Nobuyoshi Otori, James N. Palmer, Sanjay R. Parikh, Desiderio Passali, Zara Patel, Anju Peters, Carl Philpott, Alkis J. Psaltis, Vijay R. Ramakrishnan, Murugappan Ramanathan, Hwan-Jung Roh, Luke Rudmik, Raymond Sacks, Rodney J. Schlosser, Ahmad R. Sedaghat, Brent A. Senior, Raj Sindwani, Kristine Smith, Kornkiat Snidvongs, Michael Stewart, Jeffrey D. Suh, Bruce K. Tan, Justin H. Turner, Cornelis M. van Drunen, Richard Voegels, De Yun Wang, Bradford A. Woodworth, Peter-John Wormald, Erin D. Wright, Carol Yan, Luo Zhang, Bing Zhou

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    298 Citations (Scopus)


    Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR-RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR-RS-2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence-based findings of the document. Methods: ICAR-RS presents over 180 topics in the forms of evidence-based reviews with recommendations (EBRRs), evidence-based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR-RS-2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence-based management algorithm is provided. Conclusion: This ICAR-RS-2021 executive summary provides a compilation of the evidence-based recommendations for medical and surgical treatment of the most common forms of RS.

    Original languageEnglish
    Pages (from-to)213-739
    Number of pages527
    JournalInternational Forum of Allergy and Rhinology
    Issue number3
    Publication statusPublished - Mar 2021


    • acute rhinosinusitis
    • chronic rhinosinusitis
    • endoscopic sinus surgery
    • evidence-based medicine
    • recurrent acute rhinosinusitis
    • rhinosinusitis
    • systematic review


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