Interrelationship between ATP-binding cassette transporters and oxysterols

Jorge L. M. Ruiz; Lívia R. Fernandes; Débora Levy; Sérgio P. Bydlowski

doi:10.1016/j.bcp.2013.02.033

Interrelationship between ATP-binding cassette transporters and oxysterols

Jorge L. M. Ruiz, Lívia R. Fernandes, Débora Levy, Sérgio P. Bydlowski

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of membrane proteins responsible for the translocation of several substances across membranes using the chemical energy provided by ATP hydrolysis. ABC transporters participate in many physiological and pathophysiological processes, including cholesterol and lipid transportation and multidrug resistance. Oxysterols are the products of cholesterol oxidation, formed by both enzymatic and non-enzymatic mechanisms. The role of oxysterols in cholesterol metabolism and several diseases has been widely investigated, but many questions remain to be answered. Several lines of evidence link ABC transporter functions with cholesterol and oxysterol metabolism. This review discusses ABC transporters, oxysterols, and how they interact with each other.

Original language	English
Pages (from-to)	80-88
Number of pages	9
Journal	Biochemical Pharmacology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/j.bcp.2013.02.033
Publication status	Published - Jul 2013
Externally published	Yes

Keywords

Oxysterols
Cholesterol
ABC transporters
Cholesterol efflux
Multiple drug resistance

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title = "Interrelationship between ATP-binding cassette transporters and oxysterols",

abstract = "ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of membrane proteins responsible for the translocation of several substances across membranes using the chemical energy provided by ATP hydrolysis. ABC transporters participate in many physiological and pathophysiological processes, including cholesterol and lipid transportation and multidrug resistance. Oxysterols are the products of cholesterol oxidation, formed by both enzymatic and non-enzymatic mechanisms. The role of oxysterols in cholesterol metabolism and several diseases has been widely investigated, but many questions remain to be answered. Several lines of evidence link ABC transporter functions with cholesterol and oxysterol metabolism. This review discusses ABC transporters, oxysterols, and how they interact with each other.",

keywords = "Oxysterols, Cholesterol, ABC transporters, Cholesterol efflux, Multiple drug resistance",

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AU - Ruiz, Jorge L. M.

AU - Fernandes, Lívia R.

AU - Levy, Débora

AU - Bydlowski, Sérgio P.

PY - 2013/7

Y1 - 2013/7

N2 - ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of membrane proteins responsible for the translocation of several substances across membranes using the chemical energy provided by ATP hydrolysis. ABC transporters participate in many physiological and pathophysiological processes, including cholesterol and lipid transportation and multidrug resistance. Oxysterols are the products of cholesterol oxidation, formed by both enzymatic and non-enzymatic mechanisms. The role of oxysterols in cholesterol metabolism and several diseases has been widely investigated, but many questions remain to be answered. Several lines of evidence link ABC transporter functions with cholesterol and oxysterol metabolism. This review discusses ABC transporters, oxysterols, and how they interact with each other.

AB - ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of membrane proteins responsible for the translocation of several substances across membranes using the chemical energy provided by ATP hydrolysis. ABC transporters participate in many physiological and pathophysiological processes, including cholesterol and lipid transportation and multidrug resistance. Oxysterols are the products of cholesterol oxidation, formed by both enzymatic and non-enzymatic mechanisms. The role of oxysterols in cholesterol metabolism and several diseases has been widely investigated, but many questions remain to be answered. Several lines of evidence link ABC transporter functions with cholesterol and oxysterol metabolism. This review discusses ABC transporters, oxysterols, and how they interact with each other.

KW - Oxysterols

KW - Cholesterol

KW - ABC transporters

KW - Cholesterol efflux

KW - Multiple drug resistance

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DO - 10.1016/j.bcp.2013.02.033

M3 - Article

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VL - 86

SP - 80

EP - 88

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 1

ER -

Interrelationship between ATP-binding cassette transporters and oxysterols

Abstract

Keywords

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