Intra-individual changes in anxiety and depression during 12-month follow-up in percutaneous coronary intervention patients

Nikki L. Damen, Aline J. Pelle, Robert Jan M Van Geuns, Ron T. Van Domburg, Eric Boersma, Susanne S. Pedersen*

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)


Background: Only a paucity of studies focused on intra-individual changes in anxiety and depression over time and its correlates in cardiac patients, which may contribute to the identification of high-risk patients and point to targets for intervention. We examined changes in anxiety and depression over a 12-month period and the demographic and clinical correlates of change scores using an intra-individual approach in patients treated with percutaneous coronary intervention (PCI). Methods: Consecutive PCI patients (N = 715) completed the Hospital Anxiety and Depression Scale (HADS) at baseline and at 12 months post-PCI. Individual change scores were calculated and in secondary analysis, three categories of change were identified (i.e., stable, improved, and deteriorated anxiety or depression). Results: The mean individual change was -.16 (± 3.0) for anxiety and -.02 (± 2.8) for depression. In linear regression analysis, baseline anxiety levels (B = -.25, 95%CI[-.30 to -.20], p = <.001) and baseline depression levels (B = -.28, 95%CI[-.33 to -.22], p = <.001) were significant correlates of individual change scores. Secondary analysis showed that anxiety remained stable in 76.4% (546/715) of patients, while depression remained stable in 81.4% (582/715) of patients. Conclusions: The findings of the current study showed that levels of anxiety and depression remained stable in the majority of PCI patients from the index PCI to 12 months post-PCI. Future studies using an intra-individual approach are warranted to further examine individual changes in anxiety and depression over time in CAD, and PCI in particular, as a means to bridge the gap between research and clinical practice.

Original languageEnglish
Pages (from-to)464-467
Number of pages4
JournalJournal of Affective Disorders
Issue number1-3
Publication statusPublished - Nov 2011
Externally publishedYes


  • Anxiety
  • Depression
  • Intra-individual changes
  • Percutaneous coronary interventions

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