Intracellular microenvironment responsive polymers

a multiple-stage transport platform for high-performance gene delivery

Bingyang Shi, Hu Zhang, Sheng Dai, Xin Du, Jingxiu Bi*, Shi Zhang Qiao

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency.

Original languageEnglish
Pages (from-to)871-877
Number of pages7
JournalSmall
Volume10
Issue number5
DOIs
Publication statusPublished - 12 Mar 2014
Externally publishedYes

Keywords

  • controlled gene release
  • intracellular microenvironment responsive
  • multiple-stage gene delivery
  • nucleus uptake

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