Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery

Bingyang Shi; Hu Zhang; Sheng Dai; Xin Du; Jingxiu Bi; Shi Zhang Qiao

doi:10.1002/smll.201302430

Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery

Bingyang Shi, Hu Zhang, Sheng Dai, Xin Du, Jingxiu Bi^*, Shi Zhang Qiao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency.

Original language	English
Pages (from-to)	871-877
Number of pages	7
Journal	Small
Volume	10
Issue number	5
DOIs	https://doi.org/10.1002/smll.201302430
Publication status	Published - 12 Mar 2014
Externally published	Yes

Keywords

controlled gene release
intracellular microenvironment responsive
multiple-stage gene delivery
nucleus uptake

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10.1002/smll.201302430

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AU - Zhang, Hu

AU - Dai, Sheng

AU - Du, Xin

AU - Bi, Jingxiu

AU - Qiao, Shi Zhang

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KW - nucleus uptake

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Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery

Abstract

Keywords

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