Intracerebral hemorrhage location and outcome among INTERACT2 participants

Candice Delcourt; Shoichiro Sato; Shihong Zhang; Else Charlotte Sandset; Danni Zheng; Xiaoying Chen; Maree L. Hackett; Hisatomi Arima; Jun Hata; Emma Heeley; Rustam Al-Shahi Salman; Thompson Robinson; Leo Davies; Pablo M. Lavados; Richard I. Lindley; Christian Stapf; John Chalmers; Craig S. Anderson; INTERACT2 Investigators

doi:10.1212/WNL.0000000000003771

Intracerebral hemorrhage location and outcome among INTERACT2 participants

Candice Delcourt, Shoichiro Sato, Shihong Zhang, Else Charlotte Sandset, Danni Zheng, Xiaoying Chen, Maree L. Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al-Shahi Salman, Thompson Robinson, Leo Davies, Pablo M. Lavados, Richard I. Lindley, Christian Stapf, John Chalmers, Craig S. Anderson^*, INTERACT2 Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: Involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. ClinicalTrials.gov registration: NCT00716079.

Original language	English
Pages (from-to)	1408-1414
Number of pages	7
Journal	Neurology
Volume	88
Issue number	15
DOIs	https://doi.org/10.1212/WNL.0000000000003771
Publication status	Published - 11 Apr 2017
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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10.1212/WNL.0000000000003771Licence: CC BY

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Delcourt, C., Sato, S., Zhang, S., Sandset, E. C., Zheng, D., Chen, X., Hackett, M. L., Arima, H., Hata, J., Heeley, E., Salman, R. A.-S., Robinson, T., Davies, L., Lavados, P. M., Lindley, R. I., Stapf, C., Chalmers, J., Anderson, C. S., & INTERACT2 Investigators (2017). Intracerebral hemorrhage location and outcome among INTERACT2 participants. Neurology, 88(15), 1408-1414. https://doi.org/10.1212/WNL.0000000000003771

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title = "Intracerebral hemorrhage location and outcome among INTERACT2 participants",

abstract = "Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: Involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. ClinicalTrials.gov registration: NCT00716079.",

author = "Candice Delcourt and Shoichiro Sato and Shihong Zhang and Sandset, {Else Charlotte} and Danni Zheng and Xiaoying Chen and Hackett, {Maree L.} and Hisatomi Arima and Jun Hata and Emma Heeley and Salman, {Rustam Al-Shahi} and Thompson Robinson and Leo Davies and Lavados, {Pablo M.} and Lindley, {Richard I.} and Christian Stapf and John Chalmers and Anderson, {Craig S.} and {INTERACT2 Investigators}",

note = "Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2017",

month = apr,

day = "11",

doi = "10.1212/WNL.0000000000003771",

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Delcourt, C, Sato, S, Zhang, S, Sandset, EC, Zheng, D, Chen, X, Hackett, ML, Arima, H, Hata, J, Heeley, E, Salman, RA-S, Robinson, T, Davies, L, Lavados, PM, Lindley, RI, Stapf, C, Chalmers, J, Anderson, CS & INTERACT2 Investigators 2017, 'Intracerebral hemorrhage location and outcome among INTERACT2 participants', Neurology, vol. 88, no. 15, pp. 1408-1414. https://doi.org/10.1212/WNL.0000000000003771

TY - JOUR

T1 - Intracerebral hemorrhage location and outcome among INTERACT2 participants

AU - Delcourt, Candice

AU - Sato, Shoichiro

AU - Zhang, Shihong

AU - Sandset, Else Charlotte

AU - Zheng, Danni

AU - Chen, Xiaoying

AU - Hackett, Maree L.

AU - Arima, Hisatomi

AU - Hata, Jun

AU - Heeley, Emma

AU - Salman, Rustam Al-Shahi

AU - Robinson, Thompson

AU - Davies, Leo

AU - Lavados, Pablo M.

AU - Lindley, Richard I.

AU - Stapf, Christian

AU - Chalmers, John

AU - Anderson, Craig S.

AU - INTERACT2 Investigators

N1 - Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2017/4/11

Y1 - 2017/4/11

N2 - Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: Involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. ClinicalTrials.gov registration: NCT00716079.

AB - Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: Involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. ClinicalTrials.gov registration: NCT00716079.

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U2 - 10.1212/WNL.0000000000003771

DO - 10.1212/WNL.0000000000003771

M3 - Article

C2 - 28235817

SN - 0028-3878

VL - 88

SP - 1408

EP - 1414

JO - Neurology

JF - Neurology

IS - 15

ER -

Intracerebral hemorrhage location and outcome among INTERACT2 participants

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