Intralesional collagenase Clostridium histolyticum vs. verapamil injections in males with Peyronie’s disease: a prospective, matched-pair, non-blinded, randomised clinical study comparing clinical outcomes and patient satisfaction rates

Eric Chung*, Juan Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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Abstract

Purpose: To compare clinical outcomes and patient satisfaction rates between intralesional verapamil (ILV) and collagenase Clostridium histolyticum (CCH) injections in males with Peyronie’s disease (PD). Materials and Methods: Following ethics approval, PD patients were prospectively enrolled in this open-label non-blinded study. Patients were randomised to receive ILV or CCH injections with penile remodelling every fortnightly for 6 courses. Patient demographics, change in penile curvature, International Index of Erectile Function-15 and Peyronie’s Disease Questionnaire (PDQ) scores as well as overall patient satisfaction and Patient Global Impression of Improvement (PGI-I) scores were recorded at pre-treatment and 6-, 12-and 24-month post-treatment. Results: A total of 50 males were recruited and divided into ILV (n=25) and CCH (n=25) groups. The mean changes in penile curvature were-16.8 (standard deviation [SD] 7.65) degrees in ILV and-28.2 (SD 11.5) degrees in CCH groups (p<0.01). Patients in the CCH group scored better than the ILV group on the PDQ psychosexual symptoms (-2.14 vs.-2.9; p<0.01) and symptom bother score (-3.88 vs.-4.16; p=0.08). Minor treatment-related adverse events were more common in the CCH group. The overall satisfaction rate on a 5-point scale was 4.1 in ILV and 4.5 in CCH groups, and there was no statistically significant difference in the PGI-I scores between the 2 groups (p=0.14). Conclusions: CCH therapy is more effective than ILV to treat a carefully selected group of males with PD, with a reasonable safety profile and a higher high level of patient satisfaction rate in the short term.

Original languageEnglish
Pages (from-to)563-568
Number of pages6
JournalInvestigative and Clinical Urology
Volume63
Issue number5
DOIs
Publication statusPublished - Sept 2022

Bibliographical note

Copyright the Korean Urological Association. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Collagenases
  • Injections, intralesional
  • Patient satisfaction
  • Penile induration
  • Verapamil

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