Intramolecular DNA coiling mediated by a metallo-supramolecular cylinder

Michael J. Hannon*, Virtudes Moreno, Maria J. Prieto, Erlend Moldrheim, Einar Sletten, Isabelle Meistermann, Christian J. Isaac, Karen J. Sanders, Alison Rodger

*Corresponding author for this work

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

In the groove! A tetracationic supramolecular cylinder, [Fe2L3]4+ (L = C25H20N4), with a triplehelical architecture is just the right size to fit into the major groove of DNA (see picture) and too big to fit in to the minor groove. NMR spectroscopic data confirm that the cylinder binds in the major groove. Linear dichroism shows that very low loadings of [Fe2L3]4+ have a dramatic bending effect on the DNA and atomic force microscopy images show that this is an intramolecular effect resulting in coils of DNA. [graphical depiction]

Original languageEnglish
Pages (from-to)879-884
Number of pages6
JournalAngewandte Chemie - International Edition
Volume40
Issue number5
DOIs
Publication statusPublished - 2 Mar 2001
Externally publishedYes

Keywords

  • Bioinorganic chemistry
  • DNA recognition
  • DNA structure
  • Helical structures
  • Supramolecular chemistry

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