The most frequently mutated gene resulting in dominantly inherited Alzheimer's disease is presenilin-I. We have used antibodies against advanced glycation endproducts (AGE) in brain tissue sections of four patients with three different presenilin I mutations. Accumulation of intracellular AGE was observed in 75-95% of pyramidal neurons in patients with presenilin-I mutations, far exceeding the percentage of presenilin-I-, tau- or ubiquitin-positive neurons. This high level of AGE-modified proteins in vulnerable neurons is most likely explained by higher levels of their precursors (reactive (di)carbonyl products) or a slower turnover of the participating proteins. These conditions of carbonyl stress may contribute to increased neuronal dysfunction and vulnerability leading to the early disease onset.
|Number of pages||4|
|Publication status||Published - 16 Apr 2002|
- Advanced glycation endproducts
- Alzheimer's disease
- Pyramidal neurons