Intravascular large B-cell lymphoma complicated by invasive pulmonary aspergillosis: A rare presentation

Tamadur Mahasneh*, Zinta Harrington, Jonathan Williamson, Darweesh Alkhawaja, Jo Duflou, Joo Shik Shin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
10 Downloads (Pure)


We describe a patient with persisting fevers, a progressive pulmonary infiltrate, and high levels of serum lactate dehydrogenase. No underlying cause for these changes was found prior to her death despite extensive investigations. Postmortem tissue revealed invasive pulmonary aspergillosis and subsequent brain examination revealed vascular changes in keeping with intravascular large B-cell lymphoma (IVLBCL). On review, subtle yet extensive lymphomatous infiltrates involved the vasculature of multiple other organs, including the lungs. Aspergillosis is a relatively rare presenting feature of lymphoproliferative disorders, and IVLBCL is a rare subtype of diffuse large B-cell non-Hodgkin's lymphoma with, to our knowledge, very few case reports to date. Lymphoma should be considered in patients presenting with pneumonitis with bilateral lung infiltrates on imaging, with a high serum level of lactate dehydrogenase.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalRespirology Case Reports
Issue number2
Publication statusPublished - Jun 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • Cough
  • Intravascular lymphoma
  • Lactate dehydrogenase
  • Pulmonary aspergillosis
  • Pyrexia


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