Intravesical onabotulinumtoxin A injection for overactive orthotopic ileal neobladder: feasibility and efficacy

Nathan Hoag*, Vincent Tse, Audrey Wang, Eric Chung, Johan Gani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
5 Downloads (Pure)


The efficacy of intravesical onabotulinumtoxinA (BTXA) in the treatment of overactive bladder (OAB) has been well documented. The use of BTXA injection in orthotopic neobladders is yet to be studied. We present 4 cases of patients injected with intravesical BTXA for overactive orthotopic ileal neobladder. We recorded patient demographics, presenting and follow-up symptoms, urodynamic profiles, and Patient Global Impression of Improvement (PGI-I) scores. The 4 patients reported varying degrees of subjective improvements in the symptoms, including urgency, urge incontinence, and pad usage. Mean followup duration was 8.3 months (range, 5-14 months). Average PGI-I score was 3 ("a little better") (range, 2-4). To our knowledge, the current study is the first case series examining BTXA injection for orthotopic neobladder overactivity. BTXA injection yielded varying degrees of objective and subjective improvements, without significant complications. Intravesical BTXA injection is feasible and may be considered as a potential treatment alternative for OAB in orthotopic neobladders, although further study is warranted.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalInternational Neurourology Journal
Issue number1
Publication statusPublished - 1 Mar 2016
Externally publishedYes

Bibliographical note

Copyright the Publisher 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • administration
  • continent
  • intravesical
  • onabotulinumtoxina
  • overactive
  • urinary bladder
  • urinary diversion
  • urinary reservoirs


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