Intrinsically Fluorescent PAMAM Dendrimer as Drug carrier and Nanoprobe: Bioimaging and Neuron protection Study

Research output: Contribution to conferencePoster

Abstract

PAMAM dendrimers have been described as one of the most tunable and therefore potentially applicable nanoparticles both for diagnostics and therapy. In recent years, intrinsically fluorescent PAMAM dendrimers have attracted extensive attention in the fields of biological imaging and drug/gene delivery due to their excellent intrinsic fluorescence properties, functional surfaces and
highly biocompatibility. Recently, we have developed a new green intrinsic fluorescent PAMAM through simply modification with acetaldehyde. We found that the fluorescence intensity of the prepared PAMAM can be increased by 45% after heating at 70 oC, and the fluorescence spectrum is narrowed, which is beneficial to its fluorescence performance. The novel intrinsically fluorescence
PAMAM (IF-PAMAM) showed excellent biocompatibility with NSC 34 (Motor neuron like) cells, demonstrating great potential for motor neuron based biological imaging and drug delivery. In this study, we fabricated Edaravone (EDA) loaded IF-PAMAM nano-complexes and surface functionalized with transferrin (Tf), the resulting IF-PAMAM/EDV-Tf showed enhanced blood
brain barrier (BBB) transportation and elevated neuron protection function. The biological imaging performance of IF-PAMAM was evaluated by zebrafish model to provide guidance for the in-vivo application of IF-PAMAM system.
Original languageEnglish
Pages70
Number of pages1
Publication statusPublished - 2019
EventMacquarie Neurodegeneration Meeting 2019 - Sydney, Australia
Duration: 19 Jul 201919 Jul 2019

Conference

ConferenceMacquarie Neurodegeneration Meeting 2019
CountryAustralia
CitySydney
Period19/07/1919/07/19

Keywords

  • Blood brain barrier
  • Neurodegeneration disease
  • Neuron
  • Drug release
  • BBB

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  • Cite this

    Wang, G., Babazadeh, A., & Shi, B. (2019). Intrinsically Fluorescent PAMAM Dendrimer as Drug carrier and Nanoprobe: Bioimaging and Neuron protection Study. 70. Poster session presented at Macquarie Neurodegeneration Meeting 2019, Sydney, Australia.