Intrinsically Fluorescent PAMAM Dendrimer as Drug carrier and Nanoprobe: Bioimaging and Neuron protection Study

Guoying Wang, Afshin Babazadeh, Bingyang Shi

    Research output: Contribution to conferencePosterpeer-review

    Abstract

    PAMAM dendrimers have been described as one of the most tunable and therefore potentially applicable nanoparticles both for diagnostics and therapy. In recent years, intrinsically fluorescent PAMAM dendrimers have attracted extensive attention in the fields of biological imaging and drug/gene delivery due to their excellent intrinsic fluorescence properties, functional surfaces and
    highly biocompatibility. Recently, we have developed a new green intrinsic fluorescent PAMAM through simply modification with acetaldehyde. We found that the fluorescence intensity of the prepared PAMAM can be increased by 45% after heating at 70 oC, and the fluorescence spectrum is narrowed, which is beneficial to its fluorescence performance. The novel intrinsically fluorescence
    PAMAM (IF-PAMAM) showed excellent biocompatibility with NSC 34 (Motor neuron like) cells, demonstrating great potential for motor neuron based biological imaging and drug delivery. In this study, we fabricated Edaravone (EDA) loaded IF-PAMAM nano-complexes and surface functionalized with transferrin (Tf), the resulting IF-PAMAM/EDV-Tf showed enhanced blood
    brain barrier (BBB) transportation and elevated neuron protection function. The biological imaging performance of IF-PAMAM was evaluated by zebrafish model to provide guidance for the in-vivo application of IF-PAMAM system.
    Original languageEnglish
    Pages70
    Number of pages1
    Publication statusPublished - 2019
    EventMacquarie Neurodegeneration Meeting 2019 - Sydney, Australia
    Duration: 19 Jul 201919 Jul 2019

    Conference

    ConferenceMacquarie Neurodegeneration Meeting 2019
    Country/TerritoryAustralia
    CitySydney
    Period19/07/1919/07/19

    Keywords

    • Blood brain barrier
    • Neurodegeneration disease
    • Neuron
    • Drug release
    • BBB

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