Invasive physiological indices to determine the functional significance of coronary stenosis

Firas R. AL-Obaidi, William F. Fearon, Andy S.C. Yong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
57 Downloads (Pure)


Physiological measurements are now commonly used to assess coronary lesions in the cardiac catheterisation laboratory, and this practice is evidence-based and supported by clinical guidelines. Fractional flow reserve is currently the gold standard method to determine whether coronary lesions are functionally significant, and is used to guide revascularization. There are however several other physiological measurements that have been proposed as alternatives to the fractional flow reserve. This review aims to comprehensively discuss physiological indices that can be used in the cardiac catheterisation laboratory to determine the functional significance of coronary lesions. We will focus on their advantages and disadvantages, and the current evidence supporting their use.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalIJC Heart and Vasculature
Publication statusPublished - 1 Mar 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • Coronary flow reserve
  • Coronary physiology
  • Fractional flow reserve
  • Resting physiological indices


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