Invertebrate cytokines II: Release of interleukin-1-like molecules from tunicate hemocytes stimulated with zymosan

D. A. Raftos*, E. L. Cooper, D. L. Stillman, G. S. Habicht, G. Beck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Conditioned media and cell extracts from tunicate hemocytes that had been cultured with a variety of antigenic stimulants were tested for interleukin-1 (IL-1)-like activity. Media conditioned by hemocytes stimulated with zymosan significantly increased the proliferative and phagocytic activities of tunicate hemocytes. SDS-PAGE indicated that these biological activities were associated with the adaptive release of tunicate IL1-like (tunicate IL-1) molecules by stimulated hemocytes. The data suggest that tunicate IL1 molecules are expressed in response to selected antigenic stimuli. Such responses may form the basis for nonclonal, inducible immune reactions among phylogenetically primitive animals.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalLymphokine and Cytokine Research
Volume11
Issue number4
Publication statusPublished - 1992
Externally publishedYes

Fingerprint Dive into the research topics of 'Invertebrate cytokines II: Release of interleukin-1-like molecules from tunicate hemocytes stimulated with zymosan'. Together they form a unique fingerprint.

Cite this