Investigation of image segmentation methods for intracranial aneurysm haemodynamic research

Y. Sen, Y. Zhang, Y. Qian, M. Morgan

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

2 Citations (Scopus)


Patient-specific haemodynamic technology has been applied in clinical applications. Computational haemodynamic simulation is performed by utilization of geometric results obtained via medical image segmentation. However, the geometry and volume of intracranial aneurysm models are highly dependent upon different segmentation methods, even when employed upon the same medical imaging data. Moreover, methods of vascular segmentation have been insufficiently validated. In this study, we compared three segmentation methods; the Region Growing Threshold (RGT), Chan-Vese model (CV) and Threshold-Based Level Set (TLS), to segment the aneurysm geometry through the use of CTA image data. The results were evaluated via measurement of arterial volume differences (VD), local geometric shapes, and haemodynamic simulation results. We found that the maximum VD of three segmentation methods sat at around ±15%. Local artery anatomical shapes of aneurysms were likewise found to significantly influence segmentation results. The computational haemodynamic simulation was performed modelling three types of geometries, with typical haemodynamic characteristics; i.e. energy loss and shear stress. We found that there was a maximum of 58% difference between segmentation methods. The results indicated that it is essential to validate segmentation methods in order to confirm the quality of segmentation processes in the application of patient-specific cerebrovascular haemodynamic analysis.

Original languageEnglish
Title of host publicationModelling in Medicine and Biology X
EditorsR. Kiss, C. A. Brebbia
Place of PublicationBudapest, Hungary
PublisherWIT Press
Number of pages9
ISBN (Print)9781845647063
Publication statusPublished - 2013
Event10th International Conference on Modelling in Medicine and Biology, BIOMED 2013 - Budapest, Hungary
Duration: 24 Apr 201326 Apr 2013


Other10th International Conference on Modelling in Medicine and Biology, BIOMED 2013


Dive into the research topics of 'Investigation of image segmentation methods for intracranial aneurysm haemodynamic research'. Together they form a unique fingerprint.

Cite this