In an attempt to further define the genetic events in the pathogenesis andprogression of human ovarian cancer, an analysis of constitutional andovarian carcinoma DNA samples revealed loss of heterozygosity (LOH)at specific loci on chromosomes 3p (38%), 6q (23%), 11p (33%), 17p (82%)and 17q (62%). In contrast, LOH was not observed in benignorborderline tumors. No significant association could be demonstratedbetween LOH at the loci studied and tumor stage, histologic subtype, grade or patient outcome. Further analyses of large tumor panels are nowrequired to determine the relationship between LOH at these loci andthe clinicopathological behavior of ovarian tumors.
|Number of pages||6|
|Journal||International Journal of Gynecological Cancer|
|Publication status||Published - 1993|
- Allele loss
- Loss of heterozygosity
- Ovarian carcinoma