Investigation of loss of heterozygosity at specific loci on chromosomes 3p, 6q, 11p, 17p and 17q in ovarian cancer 11p, 17p and 17q in ovarian cancer

In an attempt to further define the genetic events in the pathogenesis andprogression of human ovarian cancer, an analysis of constitutional andovarian carcinoma DNA samples revealed loss of heterozygosity (LOH)at specific loci on chromosomes 3p (38%), 6q (23%), 11p (33%), 17p (82%)and 17q (62%). In contrast, LOH was not observed in benignorborderline tumors. No significant association could be demonstratedbetween LOH at the loci studied and tumor stage, histologic subtype, grade or patient outcome. Further analyses of large tumor panels are nowrequired to determine the relationship between LOH at these loci andthe clinicopathological behavior of ovarian tumors.