Involvement of quinolinic acid in AIDS dementia complex

Gilles J. Guillemin; Stephen J. Kerr; Bruce J. Brew

doi:10.1007/BF03033781

Involvement of quinolinic acid in AIDS dementia complex

Gilles J. Guillemin, Stephen J. Kerr, Bruce J. Brew^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

116 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) infection is often complicated by the development of acquired immunodeficiency syndrome (AIDS) dementia complex (ADC). Quinolinic acid (QUIN) is an end product of tryptophan, metabolized through the kynurenine pathway (KP) that can act as an endogenous brain excitotoxin when produced and released by activated macrophages/microglia, the very cells that are prominent in the pathogenesis of ADC. This review examines QUIN's involvement in the features of ADC and its role in pathogenesis. We then synthesize these findings into a hypothetical model for the role played by QUIN in ADC, and discuss the implications of this model for ADC and other inflammatory brain diseases.

Original language	English
Pages (from-to)	103-123
Number of pages	21
Journal	Neurotoxicity Research
Volume	7
Issue number	1-2
DOIs	https://doi.org/10.1007/BF03033781
Publication status	Published - 2005
Externally published	Yes

Keywords

AIDS
Chemokines
Cytokines
Dementia
HIV
Inflammatory brain disease
Kynurenic acid
Kynurenine
Macrophages
Microglia
N-methyl-D-aspartate
Quinolinic acid

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10.1007/BF03033781

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title = "Involvement of quinolinic acid in AIDS dementia complex",

abstract = "Human immunodeficiency virus (HIV) infection is often complicated by the development of acquired immunodeficiency syndrome (AIDS) dementia complex (ADC). Quinolinic acid (QUIN) is an end product of tryptophan, metabolized through the kynurenine pathway (KP) that can act as an endogenous brain excitotoxin when produced and released by activated macrophages/microglia, the very cells that are prominent in the pathogenesis of ADC. This review examines QUIN's involvement in the features of ADC and its role in pathogenesis. We then synthesize these findings into a hypothetical model for the role played by QUIN in ADC, and discuss the implications of this model for ADC and other inflammatory brain diseases.",

keywords = "AIDS, Chemokines, Cytokines, Dementia, HIV, Inflammatory brain disease, Kynurenic acid, Kynurenine, Macrophages, Microglia, N-methyl-D-aspartate, Quinolinic acid",

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T1 - Involvement of quinolinic acid in AIDS dementia complex

AU - Guillemin, Gilles J.

AU - Kerr, Stephen J.

AU - Brew, Bruce J.

PY - 2005

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N2 - Human immunodeficiency virus (HIV) infection is often complicated by the development of acquired immunodeficiency syndrome (AIDS) dementia complex (ADC). Quinolinic acid (QUIN) is an end product of tryptophan, metabolized through the kynurenine pathway (KP) that can act as an endogenous brain excitotoxin when produced and released by activated macrophages/microglia, the very cells that are prominent in the pathogenesis of ADC. This review examines QUIN's involvement in the features of ADC and its role in pathogenesis. We then synthesize these findings into a hypothetical model for the role played by QUIN in ADC, and discuss the implications of this model for ADC and other inflammatory brain diseases.

AB - Human immunodeficiency virus (HIV) infection is often complicated by the development of acquired immunodeficiency syndrome (AIDS) dementia complex (ADC). Quinolinic acid (QUIN) is an end product of tryptophan, metabolized through the kynurenine pathway (KP) that can act as an endogenous brain excitotoxin when produced and released by activated macrophages/microglia, the very cells that are prominent in the pathogenesis of ADC. This review examines QUIN's involvement in the features of ADC and its role in pathogenesis. We then synthesize these findings into a hypothetical model for the role played by QUIN in ADC, and discuss the implications of this model for ADC and other inflammatory brain diseases.

KW - AIDS

KW - Chemokines

KW - Cytokines

KW - Dementia

KW - HIV

KW - Inflammatory brain disease

KW - Kynurenic acid

KW - Kynurenine

KW - Macrophages

KW - Microglia

KW - N-methyl-D-aspartate

KW - Quinolinic acid

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DO - 10.1007/BF03033781

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SN - 1029-8428

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SP - 103

EP - 123

JO - Neurotoxicity Research

JF - Neurotoxicity Research

IS - 1-2

ER -

Involvement of quinolinic acid in AIDS dementia complex

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