IP-10/CXCL10 attracts regulatory T cells

Implication for pancreatic cancer

Serena Lunardi*, Su Yin Lim, Ruth J. Muschel, Thomas B. Brunner

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.

Original languageEnglish
Article number1027473
Pages (from-to)1-3
Number of pages3
JournalOncoImmunology
Volume4
Issue number9
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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