Abstract
Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.
Original language | English |
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Article number | 1027473 |
Pages (from-to) | 1-3 |
Number of pages | 3 |
Journal | OncoImmunology |
Volume | 4 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Jan 2015 |
Externally published | Yes |