IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer

Serena Lunardi; Su Yin Lim; Ruth J. Muschel; Thomas B. Brunner

doi:10.1080/2162402X.2015.1027473

IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer

Serena Lunardi^*, Su Yin Lim, Ruth J. Muschel, Thomas B. Brunner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.

Original language	English
Article number	1027473
Pages (from-to)	1-3
Number of pages	3
Journal	OncoImmunology
Volume	4
Issue number	9
DOIs	https://doi.org/10.1080/2162402X.2015.1027473
Publication status	Published - 1 Jan 2015
Externally published	Yes

Access to Document

10.1080/2162402X.2015.1027473

Cite this

@article{51adb34254504a8d8f6bc385238872f6,

title = "IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer",

abstract = "Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.",

author = "Serena Lunardi and Lim, \{Su Yin\} and Muschel, \{Ruth J.\} and Brunner, \{Thomas B.\}",

year = "2015",

month = jan,

day = "1",

doi = "10.1080/2162402X.2015.1027473",

language = "English",

volume = "4",

pages = "1--3",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Taylor \& Francis",

number = "9",

}

TY - JOUR

T1 - IP-10/CXCL10 attracts regulatory T cells

T2 - Implication for pancreatic cancer

AU - Lunardi, Serena

AU - Lim, Su Yin

AU - Muschel, Ruth J.

AU - Brunner, Thomas B.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.

AB - Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.

UR - https://www.scopus.com/pages/publications/84944447414

U2 - 10.1080/2162402X.2015.1027473

DO - 10.1080/2162402X.2015.1027473

M3 - Article

C2 - 26405599

AN - SCOPUS:84944447414

SN - 2162-4011

VL - 4

SP - 1

EP - 3

JO - OncoImmunology

JF - OncoImmunology

IS - 9

M1 - 1027473

ER -

IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer

Abstract

Access to Document

Other files and links

Fingerprint

Cite this