TY - JOUR
T1 - Is fatty acid intake a predictor of arterial stiffness and blood pressure in men? Evidence from the Caerphilly Prospective Study
AU - Livingstone, K. M.
AU - Givens, D. I.
AU - Cockcroft, J. R.
AU - Pickering, J. E.
AU - Lovegrove, J. A.
PY - 2013
Y1 - 2013
N2 - Background and aims: Arterial stiffness is an independent predictor of cardiovascular disease (CVD) events and all-cause mortality and may be differentially affected by dietary fatty acid (FA) intake. The aim of this study was to investigate the relationship between FA consumption and arterial stiffness and blood pressure in a community-based population. Methods and results: The Caerphilly Prospective Study recruited 2398 men, aged 45-59 years, who were followed up at 5-year intervals for a mean of 17.8-years (n 787). A semi-quantitative food frequency questionnaire estimated intakes of total, saturated, mono- and poly-unsaturated fatty acids (SFA, MUFA, PUFA). Multiple regression models investigated associations between intakes of FA at baseline with aortic pulse wave velocity (aPWV), augmentation index (AIx), systolic and diastolic blood pressure (SBP, DBP) and pulse pressure after a 17.8-year follow-up - as well as cross-sectional relationships with metabolic markers. After adjustment, higher SFA consumption at baseline was associated with higher SBP (P=0.043) and DBP (P=0.002) and after a 17.8-year follow-up was associated with a 0.51m/s higher aPWV (P=0.006). After adjustment, higher PUFA consumption at baseline was associated with lower SBP (P=0.022) and DBP (P=0.036) and after a 17.8-year follow-up was associated with a 0.63m/s lower aPWV (P=0.007). Conclusion: This study suggests that consumption of SFA and PUFA have opposing effects on arterial stiffness and blood pressure. Importantly, this study suggests that consumption of FA is an important risk factor for arterial stiffness and CVD.
AB - Background and aims: Arterial stiffness is an independent predictor of cardiovascular disease (CVD) events and all-cause mortality and may be differentially affected by dietary fatty acid (FA) intake. The aim of this study was to investigate the relationship between FA consumption and arterial stiffness and blood pressure in a community-based population. Methods and results: The Caerphilly Prospective Study recruited 2398 men, aged 45-59 years, who were followed up at 5-year intervals for a mean of 17.8-years (n 787). A semi-quantitative food frequency questionnaire estimated intakes of total, saturated, mono- and poly-unsaturated fatty acids (SFA, MUFA, PUFA). Multiple regression models investigated associations between intakes of FA at baseline with aortic pulse wave velocity (aPWV), augmentation index (AIx), systolic and diastolic blood pressure (SBP, DBP) and pulse pressure after a 17.8-year follow-up - as well as cross-sectional relationships with metabolic markers. After adjustment, higher SFA consumption at baseline was associated with higher SBP (P=0.043) and DBP (P=0.002) and after a 17.8-year follow-up was associated with a 0.51m/s higher aPWV (P=0.006). After adjustment, higher PUFA consumption at baseline was associated with lower SBP (P=0.022) and DBP (P=0.036) and after a 17.8-year follow-up was associated with a 0.63m/s lower aPWV (P=0.007). Conclusion: This study suggests that consumption of SFA and PUFA have opposing effects on arterial stiffness and blood pressure. Importantly, this study suggests that consumption of FA is an important risk factor for arterial stiffness and CVD.
KW - Arterial stiffness
KW - Blood pressure
KW - Cardiovascular disease
KW - Fatty acids
KW - Pulse wave velocity
UR - http://www.scopus.com/inward/record.url?scp=84887618332&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2012.12.002
DO - 10.1016/j.numecd.2012.12.002
M3 - Article
C2 - 23415455
AN - SCOPUS:84887618332
VL - 23
SP - 1079
EP - 1085
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 11
ER -