Is fatty acid intake a predictor of arterial stiffness and blood pressure in men? Evidence from the Caerphilly Prospective Study

K. M. Livingstone*, D. I. Givens, J. R. Cockcroft, J. E. Pickering, J. A. Lovegrove

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)

    Abstract

    Background and aims: Arterial stiffness is an independent predictor of cardiovascular disease (CVD) events and all-cause mortality and may be differentially affected by dietary fatty acid (FA) intake. The aim of this study was to investigate the relationship between FA consumption and arterial stiffness and blood pressure in a community-based population. Methods and results: The Caerphilly Prospective Study recruited 2398 men, aged 45-59 years, who were followed up at 5-year intervals for a mean of 17.8-years (n 787). A semi-quantitative food frequency questionnaire estimated intakes of total, saturated, mono- and poly-unsaturated fatty acids (SFA, MUFA, PUFA). Multiple regression models investigated associations between intakes of FA at baseline with aortic pulse wave velocity (aPWV), augmentation index (AIx), systolic and diastolic blood pressure (SBP, DBP) and pulse pressure after a 17.8-year follow-up - as well as cross-sectional relationships with metabolic markers. After adjustment, higher SFA consumption at baseline was associated with higher SBP (P=0.043) and DBP (P=0.002) and after a 17.8-year follow-up was associated with a 0.51m/s higher aPWV (P=0.006). After adjustment, higher PUFA consumption at baseline was associated with lower SBP (P=0.022) and DBP (P=0.036) and after a 17.8-year follow-up was associated with a 0.63m/s lower aPWV (P=0.007). Conclusion: This study suggests that consumption of SFA and PUFA have opposing effects on arterial stiffness and blood pressure. Importantly, this study suggests that consumption of FA is an important risk factor for arterial stiffness and CVD.

    Original languageEnglish
    Pages (from-to)1079-1085
    Number of pages7
    JournalNutrition, Metabolism and Cardiovascular Diseases
    Volume23
    Issue number11
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Arterial stiffness
    • Blood pressure
    • Cardiovascular disease
    • Fatty acids
    • Pulse wave velocity

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