Is there a role for inhaled anti-inflammatory drugs in cystic fibrosis treatment?

Zara Sheikh, Hui Xin Ong, Michele Pozzoli, Paul M. Young, Daniela Traini

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Introduction: Cystic fibrosis (CF) is a congenital life-limiting, orphan disease affecting 1/2500 – 1/3000 people worldwide with the greatest prevalence in Europe, North America and Australia. The primary reason underpinning the cause of morbidity and mortality of CF patients is associated with recurrent pulmonary inflammation and infection that leads to chronic, progressive lung deterioration and ultimately death of CF patients.

Areas covered: This review aims to explore the potential role for inhaled anti-inflammatory drugs as a more successful treatment option for CF, in comparison with current oral delivery. Specifically, the focus is on ibuprofen, the only nonsteroidal anti-inflammatory drug approved for chronic use in CF. The need for inhalation therapy has also been highlighted with an insight on the reasons and challenges associated with developing an inhalation therapy of nonsteroidal anti-inflammatory drugs (NSAIDs).

Expert opinion: There is a fundamental need to direct research towards development of anti-inflammatory drugs to control inflammation rather than just targeting infection. Development of an inhalable preparation of ibuprofen alone or in combination with an antibiotic holds the potential to be the most effective treatment option among the existing array of therapies available for CF.
Original languageEnglish
Pages (from-to)69-84
Number of pages16
JournalExpert Opinion on Orphan Drugs
Volume6
Issue number1
DOIs
Publication statusPublished - 1 Nov 2017
Externally publishedYes

Keywords

  • Cystic fibrosis
  • ibuprofen
  • inhaled therapy
  • NSAID

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