TY - JOUR
T1 - Is there AH inhibitor of na+, k+ ATPase in the plasma of normal pregnant women, or in those with pregnancy-associated hypertension?
AU - Rowe, J.
AU - Jones, M. P.
AU - Gallery, E. D M
PY - 1990
Y1 - 1990
N2 - Erythrocyte intracellular sodium [Na]i and potassium [K]i concentrations, maximum specific ouabain binding (OBmax), and Na+, K+ ATPase-dependent (ouabain-sensitive) rubidium influx (OSRb influx) were measured in women with pregnancy-associated hypertension (P-AH, pre-eclampsia) and compared with values for normotensive women in the third trimester of pregnancy. OBmax was significantly lower in women with P-AH compared with normotensive pregnant women, with a trend to higher [Na]i. There was a significant (p < 0.001) inverse relationship between OBmax and [Na]i. Although mean values for ouabain-sensitive rubidium influx in buffer were slightly lower in women with P-AH, this difference was not statistically significant. Lowest values were observed in women with proteinuric P-AH. There was no inhibition of OSRb influx by homologous plasma in groups of women with any severity of P-AH. Such inhibition was seen only in normotensive women with peripheral oedema. P-AH is associated with an abnormality of cellular Na+, K+ ATPase, but this appears to be an intrinsic abnormality and not due to the effect of a circulating factor inhibiting pump function.
AB - Erythrocyte intracellular sodium [Na]i and potassium [K]i concentrations, maximum specific ouabain binding (OBmax), and Na+, K+ ATPase-dependent (ouabain-sensitive) rubidium influx (OSRb influx) were measured in women with pregnancy-associated hypertension (P-AH, pre-eclampsia) and compared with values for normotensive women in the third trimester of pregnancy. OBmax was significantly lower in women with P-AH compared with normotensive pregnant women, with a trend to higher [Na]i. There was a significant (p < 0.001) inverse relationship between OBmax and [Na]i. Although mean values for ouabain-sensitive rubidium influx in buffer were slightly lower in women with P-AH, this difference was not statistically significant. Lowest values were observed in women with proteinuric P-AH. There was no inhibition of OSRb influx by homologous plasma in groups of women with any severity of P-AH. Such inhibition was seen only in normotensive women with peripheral oedema. P-AH is associated with an abnormality of cellular Na+, K+ ATPase, but this appears to be an intrinsic abnormality and not due to the effect of a circulating factor inhibiting pump function.
UR - http://www.scopus.com/inward/record.url?scp=0025607475&partnerID=8YFLogxK
U2 - 10.3109/10641959009012934
DO - 10.3109/10641959009012934
M3 - Article
AN - SCOPUS:0025607475
SN - 1064-1955
VL - 9
SP - 249
EP - 266
JO - Hypertension in Pregnancy
JF - Hypertension in Pregnancy
IS - 3
ER -