Is treatment-resistant depression a useful concept?

Gin S. Malhi*, Yulisha Byrow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


The term treatment-resistant depression (TRD) is widely used in the context of managing mood disorders, but defining it, both conceptually and in practice, has proven difficult. Most definitions have focused on pharmacotherapy but even these have struggled to capture the complexity of varying response and duration of treatment. Both clinically and for research studies a meaningful definition of TRD is necessary because it may lead to the development of ‘therapy-defined depressive subtypes’ and the discovery of novel antidepressants. This brief perspective critically reviews the concept of treatment resistance and how it can be more clearly defined so as to achieve a better understanding of depression and facilitate clinical treatment trials.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalEvidence-Based Mental Health
Issue number1
Publication statusPublished - 1 Feb 2016
Externally publishedYes


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