Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices

Alexander V. Lazarev; Nicolle H. Packer; Mikhail B. Bogdanov; Wayne R. Matson

Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices

Alexander V. Lazarev^*, Nicolle H. Packer, Mikhail B. Bogdanov, Wayne R. Matson

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

Abstract

Concentration, isolation and pre-fractionation of DNA adducts, glycans and glycoproteins was analyzed by using chemically modified carbn/graphite (CPAK) sample preparation devices. It was observed that higher surface hydroxylation provides unique binding affinity for selected classes of compounds including nucleotide derivatives, glycans and glycopeptides in the CAPK devices. Tightly controlled porosity, rigid column structure and chemical resistance of the devices allowed a rapid clean-up and regeneration for multiple use. These devices can be used in a wide variety of applications such as desalting and high-throughput in-gel enzymatic treatment of glycoproteins.

Original language	English
Title of host publication	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Place of Publication	Santa Fe, NM
Publisher	American Society for Mass Spectrometry (ASMS)
Pages	603-604
Number of pages	2
Publication status	Published - 2002
Externally published	Yes
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: 2 Jun 2002 → 6 Jun 2002

Other

Other	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	2/06/02 → 6/06/02

Cite this

Lazarev, A. V., Packer, N. H., Bogdanov, M. B., & Matson, W. R. (2002). Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices. In Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 603-604). American Society for Mass Spectrometry (ASMS).

Lazarev, Alexander V. ; Packer, Nicolle H. ; Bogdanov, Mikhail B. et al. / Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices. Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. Santa Fe, NM : American Society for Mass Spectrometry (ASMS), 2002. pp. 603-604

@inproceedings{9159754bbe7645f7b1d3847057bc7628,

title = "Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices",

abstract = "Concentration, isolation and pre-fractionation of DNA adducts, glycans and glycoproteins was analyzed by using chemically modified carbn/graphite (CPAK) sample preparation devices. It was observed that higher surface hydroxylation provides unique binding affinity for selected classes of compounds including nucleotide derivatives, glycans and glycopeptides in the CAPK devices. Tightly controlled porosity, rigid column structure and chemical resistance of the devices allowed a rapid clean-up and regeneration for multiple use. These devices can be used in a wide variety of applications such as desalting and high-throughput in-gel enzymatic treatment of glycoproteins.",

author = "Lazarev, {Alexander V.} and Packer, {Nicolle H.} and Bogdanov, {Mikhail B.} and Matson, {Wayne R.}",

year = "2002",

language = "English",

pages = "603--604",

booktitle = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics",

publisher = "American Society for Mass Spectrometry (ASMS)",

note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

}

Lazarev, AV, Packer, NH, Bogdanov, MB & Matson, WR 2002, Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices. in Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. American Society for Mass Spectrometry (ASMS), Santa Fe, NM, pp. 603-604, Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 2/06/02.

Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices. / Lazarev, Alexander V.; Packer, Nicolle H.; Bogdanov, Mikhail B. et al.
Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. Santa Fe, NM: American Society for Mass Spectrometry (ASMS), 2002. p. 603-604.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices

AU - Lazarev, Alexander V.

AU - Packer, Nicolle H.

AU - Bogdanov, Mikhail B.

AU - Matson, Wayne R.

PY - 2002

Y1 - 2002

N2 - Concentration, isolation and pre-fractionation of DNA adducts, glycans and glycoproteins was analyzed by using chemically modified carbn/graphite (CPAK) sample preparation devices. It was observed that higher surface hydroxylation provides unique binding affinity for selected classes of compounds including nucleotide derivatives, glycans and glycopeptides in the CAPK devices. Tightly controlled porosity, rigid column structure and chemical resistance of the devices allowed a rapid clean-up and regeneration for multiple use. These devices can be used in a wide variety of applications such as desalting and high-throughput in-gel enzymatic treatment of glycoproteins.

AB - Concentration, isolation and pre-fractionation of DNA adducts, glycans and glycoproteins was analyzed by using chemically modified carbn/graphite (CPAK) sample preparation devices. It was observed that higher surface hydroxylation provides unique binding affinity for selected classes of compounds including nucleotide derivatives, glycans and glycopeptides in the CAPK devices. Tightly controlled porosity, rigid column structure and chemical resistance of the devices allowed a rapid clean-up and regeneration for multiple use. These devices can be used in a wide variety of applications such as desalting and high-throughput in-gel enzymatic treatment of glycoproteins.

UR - http://www.scopus.com/inward/record.url?scp=2442644271&partnerID=8YFLogxK

M3 - Conference proceeding contribution

AN - SCOPUS:2442644271

SP - 603

EP - 604

BT - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

PB - American Society for Mass Spectrometry (ASMS)

CY - Santa Fe, NM

T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Y2 - 2 June 2002 through 6 June 2002

ER -

Lazarev AV, Packer NH, Bogdanov MB, Matson WR. Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices. In Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. Santa Fe, NM: American Society for Mass Spectrometry (ASMS). 2002. p. 603-604

Isolation, concentration and pre-fractionation of DNA adducts, glycans and glycoproteins using novel chemically modified carbon/graphite (CPAK) sample preparation devices

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